Application of nanotechnology in biomedicine
(Application of Nanotechnology in Biomedicine)
Second, the research significance
Nanotechnology is a comprehensive research system of preparation, research and industrialization of nano-scale substances, as well as cross-research and industrialization of nano-scale substances. Nanobiology formed by the combination of nanotechnology and biology will be an important part of life science in the 2 1 century. Nano-medicine formed by the combination of nano-technology and medicine will greatly improve medical methods and raise the level of treatment; Nanotechnology is called the manufacturing technology of 2 1 century. It will allow us to manufacture some complex molecular machines at low price, and also allow us to manufacture some tools much smaller than cells. With these tools, we can explore the mysteries of life more conveniently, carry out medical treatment at the cellular and molecular levels, and also allow us to examine biological tissues and organs in incredible details. Nanotechnology has a broad development prospect in the field of biomedicine.
Third, the academic background related to the subject.
Nanotechnology, which was studied in 1980s, made a breakthrough in 1990s. The combination of nanotechnology with biochemistry and molecular biology will have a far-reaching impact on biomedicine in the 20th century.
Nanotechnology has become one of the key technologies in 2 1 century, which is of great significance to scientific and technological progress in various fields. Previous studies have shown that nanotechnology can be applied to the fields of medicine, pharmacy, biology, chemistry and information technology. The penetration and influence of nanotechnology on medicine, bioengineering and pharmacy are obvious. Nanorobot is the most attractive content of nanotechnology in the medical field. It can be used as a miniature doctor in biomedical engineering to solve problems that doctors can't solve with traditional technology. As a new drug delivery system, the important application of nanotechnology in pharmacy-drug nano-controlled release system has been widely studied, especially in the fields of targeted and localized drug delivery, mucosal absorption drug delivery, gene therapy and protein polypeptide controlled release, etc., nanoparticles have irreplaceable advantages.
Fourth, search the database and search scope.
1, retrieve database:
(1) China periodical full-text database (accessed from 202.115.610/).
(2) Chongqing VIP Chinese sci-tech periodical database (accessed from 202. 1 15.438+0).
(3) Wanfang Database (accessed from 202. 1 15.5438+0).
(4) Cambridge Scientific Abstracts (from 202.115.61).
(5) American engineering index (input from 202.115.61.21)
2. Search scope:
Database name
hunting reserve/ground
Search type
China periodical full-text database
1994-2003
Periodical literature
Chongqing Weipu Chinese Sci-tech Periodical Database
1989-2003
Periodical literature
Wanfang database
Before 2003
Periodical literature
Cambridge scientific abstracts
1980-2003
Periodical and conference literature
American engineering index
1990-2003
Periodical and conference literature
Fifth, key words
1, nanotechnology; 2. Midosin; 3 Application (application)
Six, retrieval type
1，(T= 1)*(K=2)
2，(T= 1)*(T=2)*(K=3)
3，(U= 1)*(T=2)
4，(T= 1)*(U=2)*(k=3)
Seven. Search results
(a) China Journal Network thematic full-text database.
1, search formula 1 hit 22 articles, and selected 5 articles as follows:
2. Use search formula 2 to find 10 documents and select 5 articles, as shown below:
(2) Chongqing Weipu Chinese Sci-tech Periodical Database
1, 16 documents were hit by the search formula 1, and 5 articles were selected as follows:
2. Use search formula 2 to find 4 articles, and select 4 articles as follows:
(3) Wanfang Database
1, using search formula 3 to find 7 articles and select 5 articles, as shown below:
2. Using the search formula 1, two documents were found and two documents were selected, as shown below:
Cambridge scientific abstracts
1, search formula 1 hit 28 articles, and selected 5 articles as follows:
2. Search Formula 3 found 48 articles and selected 5 articles as follows:
(5) American Engineering Index
1, 9 documents were hit by the search formula 1, and 5 documents were selected as follows:
2.9 articles were hit by search formula 3, and 5 articles were selected as follows:
Eight. Evaluation of retrieval effect:
In the full-text database of China journals, 22 articles were hit by the search formula 1, and 10 articles were hit by the search formula 2. In the full-text database of VIP China sci-tech periodicals, 16 articles were hit by the search formula, and 4 articles were hit by the search formula 2. In Wanfang database, 7 documents were hit by search formula 3, and 2 documents were hit by search formula 1. In the Cambridge Scientific Abstracts database, 28 articles were hit by the search formula 1 and 48 articles were hit by the search formula 3. American engineering index hits 9 articles with the search formula 1***, and 9 articles with the search formula 3***.
The retrieval field and retrieval technology have great influence on the retrieval effect. Secondly, we should correctly select the search fields, such as the title field and keyword field for the highly specific search words, and any field for the poorly specific search words. Using proximity retrieval technology to improve precision and recall. From the field of retrieval, the precision of using the title field is higher than that of using other fields, which is more in line with the requirements of the topic. When the detected literature information is less, it is best to use any field (also called full-text field).
China Journal Network full-text database and VIP Chinese sci-tech journal database have high precision and recall, almost all of them provide full-text for free and online printing. Both databases can download titles, among which VIP can choose to download current records, marked records and all records. Since 2002, VIP has collected a total of 1989+02000 periodicals. The number of 5,300 periodicals included in China Periodical Network is from 1994 to 2002. The retrieval results of VIP can't be sorted, but the retrieval results of China Journal Network can be sorted in three ways: unordered, relevant and updated date. China Journal Network provides initial and advanced retrieval methods, while VIP provides same-field retrieval and converted-field advanced retrieval. In terms of semantic standardization, VIP has a thesaurus of synonyms and authors with the same name.
Nine. Overview:
Nano-scale technology is a high-tech subject that manipulates atoms and molecules on the spatial scale of 0 1- 100nm, processes materials, manufactures products with specific functions, or studies a substance to master the motion laws and characteristics of its atoms and molecules. The field of nanotechnology includes not only nano-electronics, but also nano-materials, nano-manufacturing, nano-biology, nano-microscope and nano-processing technology. It was born on the basis of the combination of modern physics, chemistry and advanced engineering technology, and it is a new science and technology closely combined with high technology. Biomedical engineering is a frontier subject developed by combining modern life science, medicine and engineering. [004]
Nanotechnology, which was studied in 1980s, made a breakthrough in 1990s. [0 18] The combination of nanotechnology with biochemistry and molecular biology will have a far-reaching impact on biomedicine in the 20th century.
Nanotechnology has become one of the key technologies in 2 1 century, which is of great significance to scientific and technological progress in various fields. Previous studies have shown that nanotechnology can be applied to the fields of medicine, pharmacy, biology, chemistry and information technology. The penetration and influence of nanotechnology on medicine, bioengineering and pharmacy are obvious. Nanorobot is the most attractive content of nanotechnology in the medical field. It can be used as a miniature doctor in biomedical engineering, which solves the problems that doctors can't solve with traditional technology. As a new drug delivery system, the important application of nanotechnology in pharmacy-drug nano-controlled release system has been widely studied, especially in the fields of targeted and localized drug delivery, mucosal absorption drug delivery, gene therapy and controlled release of protein and polypeptide. [0 15]
Nanobiology formed by the combination of nanotechnology and biology will be an important part of life science in the 2 1 century. Nano-medicine formed by the combination of nano-technology and medicine will greatly improve medical methods and raise the level of treatment; Nanotechnology is called the manufacturing technology of 2 1 century. It will allow us to manufacture some complex molecular machines at low price, and also allow us to manufacture some tools much smaller than cells. With these tools, we can explore the mysteries of life more conveniently, carry out medical treatment at the cellular and molecular levels, and also allow us to examine biological tissues and organs in incredible details. [0 12]
Looking at the research progress of nanotechnology in biomedical engineering at home and abroad in recent years, it is found that nanotechnology and nanomaterials play an important role in improving the bioavailability of drugs, controlling the release system, improving the targeting of drugs, and establishing new ways of administration. These studies have brought new hope for the modernization of traditional Chinese medicine. [0 10]
One of the core development directions of nanotechnology application is its research and development in life science and human health care. At present, nano-functional materials and devices are not only applied and developed in the structural and functional detection of biological macromolecules such as DNA, RNA and protein, but also it is particularly important to form many applicable technologies in the medical field, including the application of nano-materials and technologies in nano-drug systems, nano-material labeling and single molecule detection technologies, the application of nano-materials and devices in the diagnosis and treatment of major clinical diseases, nano-materials application and rehabilitation equipment and artificial organs. Based on this, the main application research of biomedical nanotechnology is summarized. [0 1 1]
Nanotechnology is a key point in the development of science and technology in the world today. Nanotechnology and nanomaterials have broad prospects in bio-environmental protection and biomedical applications, and will have a far-reaching impact. [008] The strategic position of nanotechnology in the scientific and technological revolution in the 2 1 century and its broad application prospects in the fields of electronics, information, biomedicine, military affairs, aerospace and so on will surely promote the arrival of the new industrial revolution in the 2 1 century. [008]
X. learning experience
2 1 century is the information age. Obtaining information quickly and effectively from the vast ocean of knowledge is an important technology that every modern person should and must master. We college students, in particular, should strive to improve their ability to use information to analyze and solve problems. Through the study of this course, I have mastered the retrieval methods and skills of periodical literature information and patent literature information at home and abroad, and learned to use Boolean retrieval. Using retrieval techniques such as word position retrieval, cut-off retrieval, restricted retrieval, etc., the computer retrieval formula is compiled to retrieve literature information quickly and accurately, and how to process and sort out the detected information is preliminarily understood. In the retrieval practice, I have personally experienced the unique advantages and disadvantages of various information databases at home and abroad, mastered certain retrieval skills, and learned that the selection of retrieval words will affect the recall rate and the selection of retrieval fields will affect the precision rate. The combination of search words directly affects the retrieval efficiency. Through the comprehensive report, I learned to analyze and synthesize the data in my hand, and got the current research trends in this direction at home and abroad from the retrieved existing data, so as to get the research direction that I should start and avoid starting again on the work that others have already done. Moreover, I can get the relevant content of research direction by searching academic papers and patents at home and abroad, and learn from the results. You don't have to start from scratch, saving time and energy. In a word, this course provides a very important research method and is an indispensable preparation tool for scientific research. Learning this course well has laid a solid foundation for completing graduation thesis, postgraduate thesis and future scientific research. In the process of making a comprehensive report, I encountered many problems. Through my own serious thinking, repeated experiments and communication with my classmates, all the problems have been solved and my thinking has been exercised.