1. Prevention of HPV subtypes
Whether it is an imported or domestic bivalent HPV vaccine, the subtypes it prevents are HPV16 and HPV18
Two types of HPV The vaccines are all approved to prevent cervical cancer and cervical cancer in situ caused by infection with HPV16 and 18.
The instructions for the imported bivalent HPV vaccine mention that it is effective against HPV31/33 and 45 It has a cross-protective effect, but there is no evidence that it can prevent related diseases caused by several HPV subtypes
2. Antibody persistence
Antibody persistence for HPV16 and HPV18 , there is not much difference between the two vaccines
Among them, the HPV16 antibody positivity rate of Chinese-made Xinconin can reach 100 at 66 months after vaccination, while the imported Cervarix HPV16 antibody positivity rate can reach 100 at 60 months after vaccination. The positivity rate was also 100, which dropped to 99.6 by the 72nd month.
In terms of HPV18 antibody persistence, the domestic Xinconin was 98.3 after the 42nd month, and the imported Cervarix was 98.3 after the 48th month of vaccination. The last one is 99.3;
Because the age groups of the sample data and the value time are different, the data will be slightly different~
If it seems to be more troublesome, the editor will help you summarize it. Below: The two are basically the same in terms of antibody concentration and persistence of HPV16 and 18 types
3. Other comparisons
Expression system:
Two types of antibodies Both HPV vaccines are recombinant human papillomavirus vaccines. Cervarix uses an insect cell expression system, while Xingconin uses an E. coli expression system, which has high production capacity and low cost, so the price is lower
Characteristics:
The domestic bivalent is packaged in vials, and the imported bivalent is prefilled packaging
Generally speaking, there is not much difference between the imported bivalent and domestic bivalent HPV vaccines. .
4. Price analysis
The price of domestic Xinconin is about 350 yuan per shot, and the imported Xinconin is about 605 yuan per shot. Therefore, relatively speaking, the price of domestically produced 2 The price/performance ratio will be higher, but the domestic 2-price drug has not been on the market for a long time, and it will take time to verify the long-term immune maintenance effect.
No matter which vaccine you choose, the earlier you get vaccinated, the earlier you will be protected and the higher the cost-effectiveness.