Medical insurance class b
39.80 yuan/box
Levamlodipine besylate tablets (trade name: Shihuida) is a major scientific research project of China Academy of Sciences in the Ninth Five-Year Plan, which was developed by Institute of Applied Chemistry of China Academy of Sciences. Levamlodipine besylate tablets are the first chiral resolution optically pure drug in China and the first chiral resolution antihypertensive drug in the world. 1995, Pfizer, USA issued a patent on the active ingredient of amlodipine, which proved that the curative effect of levoamlodipine was 1000 times that of dextroamlodipine (Arrowsmith, J.E.; and
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Levamlodipine besylate tablets were approved for marketing by National Medical Products Administration 1999.
Levamlodipine besylate tablets (Shihuida) belong to the national essential drugs, and are classified as Class B medical insurance products, which are the first-line drugs for the treatment of hypertension.
After the listing of Levamlodipine besylate tablets, a multicenter randomized double-blind study was conducted in more than 60 well-known hospitals in China. The results show that:
1. Shihuida has good pharmacokinetics.
* The half-life is 49.6 hours, which is the longest of its kind;
* The peak time of blood drug concentration is about 6- 12 hours, and it reaches a steady state in about one week, forming a dynamic balance and no drug accumulation;
* The bioavailability is 64-80%, which is the drug with the highest bioavailability among similar drugs.
In 2003, it was awarded the patent of chiral resolution method by the United States.
2. Shihui Danone stably controls blood pressure and protects rake organs.
Gu Feng ratio (T/P value) is 85%, which fully meets the gold standard of FDA.
3. Continue to control blood pressure steadily after taking 1-2 days.
4. Shihuida has a wide range of applications: it is suitable for elderly patients, heart failure, diabetes, kidney disease, asthma/bronchitis and other patients.
Shihuida is a chiral optical pure drug, which has obtained the patent of American method. China holds two patents: material and method. The patent protection period is 20 years.