When was berberine tablets invented?

The new synthetic process of berberine developed by Northeast Pharmaceutical General Factory recently won the national invention patent. The process route of artificial synthesis of berberine in this factory was successfully developed in the mid-1970s. 198 1 year, the state invested heavily in building a production line with an annual output of 30 tons, but due to the high production cost, it could not compete with the extraction of berberine from plants, and it was dismantled in 1994. 1999, the factory researched and developed a new synthesis process, which increased the sales of berberine by about10.70 billion yuan and the net profit by 2.710.40 billion yuan. Compared with plant extraction, artificial berberine technology has absolute advantages in cost and quality, which can effectively avoid serious damage to the environment caused by plant extraction.