Bose is a patent of L 'Oreal cosmetics, which has anti-aging effect, so it can't be used with products containing fruit acid and salicylic acid. Salicylic acid is very irritating and easy to hurt the skin, and Bose has a strong effect. It is best not to use them together. It is good to mix mild ingredients, but it is easy to hurt the skin when two strong irritants are used together.