Biomedical textile project team and cooperative hospitals have carried out a series of studies on raw material selection, product structure and shape design, preparation technology and product performance evaluation of artificial blood vessels for transplantation and endovascular isolation.
Great achievements have been made in the development of suture, straight tube and bifurcated ultra-thin and ultra-dense high-strength artificial blood vessels. Supported by four provincial and ministerial projects such as National Natural Science Foundation of China, Ministry of Education and Shanghai Science and Technology Commission, it has 15 patents.
Based on the function and function of in vivo graft and intravascular graft, the testing method of biomechanical properties was studied. According to the structural characteristics of artificial blood vessels, the characterization indexes, testing instruments and testing methods are established.
The main testing instruments independently developed are: artificial blood vessel permeability tester, artificial blood vessel fatigue tester, artificial blood vessel compliance tester, artificial blood vessel wall wear tester and so on. Has 6 related patents.
The main disadvantages of artificial blood vessels are thrombosis and infection.
1. Thrombosis: During the implantation of artificial blood vessels, patients need systemic heparinization to avoid thrombosis of artificial blood vessels during the operation, which will lead to the failure of the operation.
If the effect of systemic heparinization during operation is poor, or the patient fails to take the medicine on time according to the doctor's advice after discharge, and there is no regular review, because the joint of artificial blood vessel is not as smooth as the original blood vessel, the hemodynamics will be changed, and platelets will gather locally, thus forming thrombus.
Therefore, anticoagulation and antiplatelet therapy should be given after operation, especially anticoagulation therapy. Low molecular weight heparin sodium injection can be used under the guidance of doctors during hospitalization, and low-dose rivaroxaban tablets and aspirin enteric-coated tablets should be taken for a long time after discharge to prevent thrombosis in artificial blood vessels.
2. Infection: In the process of artificial blood vessel implantation, aseptic operation must be strictly carried out, and blood routine should be checked after operation to observe the changes of inflammatory indexes. Use broad-spectrum antibiotics for anti-infection treatment for about 3 days, such as compound tetracycline tablets, and extend the use time of antibiotics if necessary.
Because the blood supply of artificial blood vessels is not rich, the infected lesions are difficult to be eliminated by autoimmunity, so if the wound is not cleaned properly after operation, bacteria may breed, leading to artificial blood vessel infection.