1, powder coating-fluidized bed bottom spraying, often coated with E 100, because it is inevitable that some powder remains on the patch pocket without coating, and a small amount of coated products are inevitably mixed in the unloading process, which cannot cover up the bitterness of 100%.
2. Coated pellets-The smallest MCC pellets below 80 mesh are coated, and the effect is good, but due to the limitation of drug loading, the dosage above 30mg is basically unacceptable.
3. Melt extrusion granulation method-hot melt extrusion of waxy materials into fine particles, which has a slow release effect. Azithromycin sustained-release dry suspension is just like this, with limited equipment, patents and drug thermal stability.
4. Preparation of microcapsules by spray drying-the encapsulation rate will not exceed 80%, and industrialization requires an inert gas internal circulation solvent recovery system and an explosion-proof system.
According to the dosage of ofloxacin, only hot melt extrusion granulation method can be used. Get ready for the challenge.