Scientific Research in College of Biological Sciences and Engineering, Fuzhou University

(1) scientific research:

For a long time, the college has adhered to the road of combining scientific research with teaching. Teachers actively participate in scientific research activities while teaching, and promote the improvement of teaching quality through scientific research.

At present, the college has scientific research institutions such as Fuzhou University Institute of Bioengineering, Institute of Pharmaceutical Biotechnology, Food Biochemistry Laboratory, Applied Ecology Laboratory and Biological Humic Acid Laboratory. The academic leaders are Professor Rao Pingfan, Dean Ye and Professor Guo, and there are a number of academic backbones with scientific research and teaching strength and initiative, including Associate Professor 12 (,,,,,,,,,Wang Shaoyun, Liu Shutao, Li Hao, Zhou Jianwu, etc. ) under the age of 40, in which the school employs a responsible professor.

The scientific research team of the College has formed a team in protein in the fields of enzyme engineering, pharmaceutical biotechnology, food biochemistry, aquaculture and so on, which has certain influence at home and abroad:

1. protein and the direction of enzyme engineering: isolation, purification and characterization of functional protein (upstream), gene cloning, recombination and construction of expression strains (midstream), large-scale preparation and production (downstream). This direction is the focus of today's biology-an important part of systems biology represented by functional genomics and protein omics, which will lay the foundation for truly realizing the century of biotechnology in 2 1 century.

Among similar disciplines in China, this direction has obvious advantages in the separation, purification and characterization, large-scale preparation and production of protein. However, compared with the top research institutions in protein, the research on basic theory needs to be strengthened.

2. The direction of medical biotechnology: This research direction is characterized by studying the internal dynamics and macro-process dynamics of key biochemical products and biochemical processes, separating and purifying related biochemical products, and realizing engineering amplification and process optimization. The research direction includes: optimization of microbial reaction process, development of new bioreactor and separation and purification of related new biochemical products.

Study on the Characteristics and Optimization of (1) Microbial Process

This direction is mainly engaged in the research of internal dynamics and process dynamics of microbial reaction, and carries out the optimization of biological reaction process and the optimal design and control of related reactors to realize the efficient operation of the target biochemical reaction process.

(2) Research on new environmental bioreactor.

Aiming at the anaerobic biodegradation process of high-concentration organic wastewater and low-concentration domestic wastewater, the characteristics of anaerobic bioreactor were emphatically studied, the optimal control measures of bioreactor were discussed from the engineering and microbial perspectives, and practical related wastewater biological treatment technologies were developed.

(3) New biochemical separation technology

Biochemical separation engineering plays an important role in biotechnology. This direction mainly studies the new technology and process of biochemical separation according to the characteristics of biochemical reaction products. Membrane separation, chromatographic separation, ion exchange separation and supercritical fluid extraction are emphatically introduced.

(4) In this research direction, the research focus of pharmacogenomics led by Professor Hong is the screening of medicinal microorganisms, strain improvement, microbial pharmacogenomics, cloning of resistance genes, cloning of antibiotic biosynthesis gene clusters, gene knockout, gene closure, gene replacement, cell engineering breeding, regulation of metabolic network of secondary metabolites and optimization of fermentation process, separation, extraction and purification of antibiotics, and industrialization of antibiotics. Among them, tobramycin-producing bacteria have been industrialized through quality improvement and optimization, and the technical indicators have reached the leading level in China. The gene cluster cloning of micromonospora eneuvensis, a high-yield strain of sisomicin with different genetic traits, made a breakthrough, applied for a patent and won the third prize of provincial scientific and technological progress, which filled the gap in this research field in China. Other varieties studied include kanamycin, gentamicin, tobramycin, micronomicin, sisomicin, ribomycin, chlortetracycline, oxytetracycline, tetracycline, rifamycin, erythromycin, cyclosporine A, cephalosporin, clavulanic acid, vancomycin, cyclosporine A and so on. Most of its production technical indicators have been higher than the level of industrialization.

3. Food biochemistry direction: based on solid biochemical science, carry out research on traditional foods. Specifically, the current research direction is 1. Research on food analysis methods II. Research on traditional food in protein. Study on traditional food fermentation. Introducing the latest analytical methods is the premise of breaking through the traditional food research. The new methods developed by this discipline to analyze the composition and function of food by chromatography and capillary electrophoresis effectively reveal the composition and mechanism of traditional food, and reflect the in-depth research work and the advantages of means. Under the trend of imitating and tracking the international ready-made food science and technology, this discipline insists on the research of China traditional food, which is considered as the sacred duty to build the core competitiveness of China food industry and the foundation for this discipline to stand on its own feet in the forest of international food science and technology.

The biochemical basis of coolness of yellow rice wine, Fuzhou meat swallow, tofu and Chinese fruit was studied in this direction, which provided a new perspective for people to understand these important traditional foods at the molecular level and laid the foundation for the industrialization and internationalization of related foods. These efforts have been supported by the food industry at home and abroad, and a brand-new situation of industry-university cooperation has emerged, which is entering a fruitful harvest season.

Another notable feature of this direction is that it has rare successful entrepreneurial experience in academic circles, strong industrialization ability, and natural advantages in communication with the food industry, realizing high-level technical cooperation and exchanges with domestic and even international food enterprises. At present, R&D institutions have been established with Shengnong Group, Crayon Shinchan, Fumaji Group and other three major food enterprises in Fujian Province. The cooperative research of Nestle, Danone, Effen, Ajisen and other companies has begun. This topic is becoming a technical power source to promote the development of food industry in our province.

The outstanding weakness of this discipline lies in the lack of communication skills in seeking government resources to support the forward-looking research of this discipline.

4. Direction of applied ecology:

(1) Develop a brand-new inland culture technology for marine fish, which has been successful in the culture of Penaeus vannamei and grouper, and is now being popularized in the mainland. This technology can not only avoid the potential risks brought by the changeable and harsh climate in the sea area, but also make full use of land resources, artificially improve ecological conditions, shorten the growth cycle and reduce production costs.

(2) The new technology of freshwater fish ecological culture has been successful in turtle and tilapia culture, and turtle culture has been extended to Fujian, Zhejiang, Guangdong, Jiangxi, Hainan and other provinces, and achieved great economic and social benefits. Associate Professor Yuan Chonggui, an academic leader, was called Dr. Gui by farmers.

(2) Science and technology service industry

1. Science and technology first serve undergraduate and postgraduate education. Our college actively serves undergraduate teaching by using the software and hardware conditions of key disciplines and scientific research institutions. In recent years, the scientific research team, SRTP scientific research training and scientific research innovation activities carried out by undergraduates in our college are among the best in the whole school, and they have won more than 30 awards in the national college students' entrepreneurship competition and scientific and technological innovation organized by the National Association for Science and Technology.

At present, taking the laboratory construction of the new campus as an opportunity, we will build the Biological Experiment Center of the Ministry of Education, the Biomedical Engineering Technology Experiment Center of universities directly under the Ministry of Education and the Fujian Medical Bioengineering Technology Innovation Platform. These experimental and innovative platforms not only enable students to master new technologies, but also stimulate their scientific exploration and innovative spirit.

2. Science and technology serve local construction. In recent years, our institute has made gratifying achievements in the development of science and technology. Horizontal funds have doubled for three consecutive years. In 2006, the per capita expenditure was nearly 654.38 million yuan, ranking second in the whole school for two consecutive years, and it was an advanced unit for the application and promotion of science and technology. Liu Shutao and other teachers have successively won advanced individuals in science and technology promotion.