Safety and dosage of GSPE
Through the experimental research of relevant personnel, the acute toxicity test LD50 in rats is >10kg, which belongs to the actual non-toxic level; the 90-day subchronic feeding test in rats has not Toxicity symptoms and mouse genotoxicity tests were all negative, proving that it is non-toxic, non-teratogenic and safe, and can be widely used in food and other fields. There are currently no international regulations on the dosage of grape seed proanthocyanidins. The generally recommended dosage as a dietary supplement in Europe, the United States, Japan and other countries is 100 to 300 mg/d.