Explain in detail the relationship between environmental endocrine disruptors and pesticides.

Table 5. 13 Some pesticides and metabolites with endocrine disrupting effects and their mechanism of action

Mechanism of pesticide names affecting hormone system

I pesticides and acaricides

1 ehrlich estrogen binding er; Compete with estradiol

The estrogenic mechanism of 2d- trans-permethrin is unknown.

The thyroid mechanism of bhc is not clear.

The mechanism of action of carbaryl estrogen and progesterone is not clear.

5 clofentezine thyroid enhances thyroid hormone secretion.

The mechanism of testosterone and progesterone in chlordane is not clear.

The mechanism of cypermethrin interfering with reproductive function is not clear.

The mechanism of phenol and estrogen poisoning is not clear.

9DDT estrogen combines with ER, including imitating and resisting estrogen, changing the pattern of hormone synthesis or metabolism, and changing the level of hormone receptor.

10 DDT metabolite androgen inhibits androgen binding to receptor; Induction of androgen transformation in developing, adolescent and adult male rats and the role of hormones

1 1 dicofol estrogen shows an affinity for binding with androgen and ER.

12 dieldrin estrogen binding er; Compete with estradiol

The estrogenic mechanism of endosulfan 13 is not clear.

14 cartap anti-androgen competitive androgen receptor antagonist

The estrogenic mechanism of 15 fenvalerate is unknown.

The mechanism of 16 heptachlor thyroid is unknown.

Metabolites of 17 heptachlor epoxide/heptachlor procreation

18 cypermethrin hypothyroidism reduces serum thyroid hormone; Directly affect the thyroid gland?

19 lindane inhibits the binding of estrogen/androgen ligands to estrogen and androgen receptors.

Malathion thyroid may significantly reduce the level of thyroid hormone in serum by directly affecting thyroid.

The thyroid mechanism of methomyl 2 1 is unknown.

The mechanism of action of 22 methoxyestrogen is not clear.

Potential thyroid antiandrogenic activity of mirex; Inhibit the production of luteinizing hormone

24- trans -9- chloroestrogen ER activator

The reproductive mechanism of chlordane oxide is not clear.

The mechanism of action of 26 permethrin estrogen is not clear.

The mechanism of action of fenvalerate androgen is unknown.

Ⅱ. Fungicides

28 ethylenethiourea thyroid thyroid peroxidase inhibitor

Fenarimol estrogen receptor antagonist

30 Nitrile Benzazole Thyroid Enhances Thyroid Hormone Secretion

The mechanism of 3 1 iprodione inhibiting testosterone synthesis is unknown.

Mancozeb thyroid peroxidase inhibitor

Ethylenethiourea is a metabolite of the 33rd generation of Thyroid, which inhibits the synthesis of thyroid hormone.

The mechanism of thyroid gland in the 34th generation of Senlian is unknown.

Procymidone androgen receptor inhibitor

36 pyrimethanil thyroid enhances thyroid hormone secretion.

T _ 4 of pituitary gland and thyroid gland decreased, while thyrotropin increased.

38 triazolone estrogen receptor activator

39 triazole estrogen er activator

Vinyl sclerotia can antagonize androgen, compete with androgen for androgen receptor (AR), inhibit the binding with androgen receptor -DNA, and change the expression of androgen-dependent genes.

4 1 zineb's thyroid metabolite ETU inhibits the synthesis of thyroid hormone.

Thiram inhibits iodide peroxidase, which is similar in structure to thiram and can be metabolized into thiram in the environment.

Ⅲ. Herbicide

Acetochlor decreased thyroid hormone level and increased T4.

Alachlor decreased the level of thyroid hormone and increased T4.

Herbicide strong thyroid peroxidase inhibitor, inhibiting thyroid hormone synthesis.

Atrazine neuroendocrine pituitary and testosterone metabolism inhibitory ligands bind to androgen and estrogen receptors.

47 Ligulon androgen receptor antagonist

The thyroid mechanism of azithromycin is unknown.

The herbicide ether thyroxine is similar to thyroid hormone in structure; Herbicide ether or its metabolites may have thyroid hormone activity.

50 pendimethalin thyroid enhances thyroid hormone secretion.

5 1 heptachlorophenyl thyroid enhances thyroid hormone secretion.

Thyroid aminopropionate enhances thyroid hormone secretion.

The reproductive/metabolic mechanism of trifluralin is not clear.