Is there a chance to grant a patent after two opinions?

Yes But it depends on the specific situation: if the examiner thinks that a reply has overcome the defects pointed out by the examination opinions, and there are no other defects in the application documents, he will generally be notified of the grant of the patent right in two or three months. If the examiner thinks that a reply does not overcome the defects pointed out, or there are new defects in the revision, then he will send you a second reply. At this time, you need to reply to the second reply, and you can only authorize it after overcoming the defects.