In 1907, ehrlich and Bertheim clarified that the real chemical structure of atoxic is the monosodium salt of aminophenylalanine. Later, ehrlich and his colleagues conducted experiments on the therapeutic effects of atoxic and a large number of atoxic derivatives provided by industrial chemists.
1909, ehrlich's assistant, Qin Zuobalang, discovered that there was a Atok West derivative with the number of 606, which had therapeutic effect on rabbits infected with syphilis. Previously, this compound has been used in laboratories in ehrlich. Somehow, I found that there was no effect on syphilis, so I didn't do any further testing. Qin Zuobalang is a careful and dedicated expert in syphilis experiment. He tried again and achieved unexpected success. Subsequently, his experiments on chimpanzees and humans were also successful. In that year, we obtained the patent of "Ehrlich-Qin 606".
The following year, this discovery was first announced at the conference of internal medicine in Wiesbaden, Germany, which caused a sensation around the world. Ehrlich provided 65,000 copies of medicines to patients free of charge. Ehrlich often said that success requires four G's: "GEULD, Geschick, Geld, Glück" (patience, ability, capital and luck). Talking about the success of 606, he said: "After several years of bad luck, now my luck has finally turned."
Ehrlich named this new drug "Salvarsan" (chemical name of safe arsenic agent: diamino-arsenic dioxides). If used properly, it can effectively kill Treponema pallidum, especially if it is applied as soon as possible after infection, and the curative effect is better. However, ehrlich's dream of inventing an ideal antibacterial agent (magic bullet) has not really come true in Solfo powder, because it has side effects, and at low doses, it will also make spirochetes resistant to drugs.
But this discovery, as the most effective method to treat sexually transmitted diseases at that time, has great practical significance. At the beginning of the 20th century, syphilis was a terrible infectious disease, just like AIDS today. Salfo powder has restored countless patients to health. 19 12 years, ehrlich invented the modifier "new solvo powder" (also known as 9 14), which has excellent curative effect and is more soluble in water than 606.