Applying for patent number CN00113649.6
The present invention discloses a preparation method of water-soluble chitosan. It is deacetylated with 2 to 4 times of 55 to 70% concentrated sodium hydroxide at 75 to 95°C for 10 to 20 hours to obtain crude chitosan; it is then hydrolyzed and purified at 5 to 25°C to obtain water-soluble chitosan. Chitosan boutique. The chitosan prepared by the method of the present invention can be dissolved in water, is well absorbed by the human body, has a good inhibitory effect on tumors, and can be made into a variety of soluble medical and health care products.
Applying for patent number 98126756.4
The present invention discloses a method for preparing water-soluble chitosan derivatives. The method is based on the repeating units of chitosan, at 20- It reacts with substituents containing hydroxyl and carboxyl groups in a low-carbon alcohol solution of sodium hydroxide at a temperature of 80°C. The derivative is water-soluble and has a high intrinsic viscosity.
Preparation method of water-soluble chitosan with controllable molecular weight
A method for preparing water-soluble chitosan with controllable molecular weight, which fully combines chitosan with various deacetylation degrees Dissolve in hydrochloric acid, slowly add sodium hypochlorite-hydrogen peroxide as an oxidizing agent, and react at room temperature to break the 1,4-β-D-glycosidic bond to generate low molecular weight water-soluble chitosan. The process of the invention is simple, the low molecular weight chitosan prepared has good water solubility, and the main chain structure of the chitosan is retained. It can not only be used as a raw material for oral drugs and health care products, but also can be used as an additive in the cosmetics and food industries. .
Sovereignty
Claim 1. A method for preparing water-soluble chitosan with controllable molecular weight, characterized by dissolving chitosan in 0.1 mol/L hydrochloric acid solution to form a 2% by weight chitosan solution, filter out the insoluble matter and stir thoroughly, slowly add 0.05-0.1M sodium hypochlorite, the molar ratio of chitosan to sodium hypochlorite is 5-50: 1, stir evenly and then gradually Add 0.1-2M hydrogen peroxide dropwise. The molar ratio of chitosan to hydrogen peroxide is 1-25:1. Continue stirring. After the reaction is completed, concentrate the reaction solution in vacuum, filter out the insoluble matter, and store the filtrate at room temperature. Concentrate under reduced pressure, precipitate with methanol, wash thoroughly, and dry under vacuum to obtain low molecular weight water-soluble chitosan.
Preparation methods and research progress of oligomeric water-soluble chitosan
Jin Xinrong Chai Pinghai "Progress in Chemical Industry", Volume 17, Issue 2, 1998
East China Department of Chemistry, Polytechnic University
Abstract: The preparation of oligomeric water-soluble chitosan is a very hot research topic at present. This article discusses various methods of chitosan degradation to prepare oligomeric water-soluble chitosan. and current research progress are reviewed.