niú huáng jiàng yā wán 2 English Reference
Besoar Blood Pressure—Overview of Reducing Pills 3
Niuhuang Jiangya Pill is a prescription name, which comes from Chinese People's Pharmacopoeia (a 2 edition) [1]. Pharmacopoeia of the People's Republic of China (21 edition) records the pharmacopoeia standard of this Chinese patent medicine. Composition
antelope horn, pearl, buffalo horn concentrated powder, bezoar, borneol, realgar, cassia obtusifolia, codonopsis pilosula, radix astragali, radix paeoniae alba, Rhizoma Chuanxiong, Scutellariae Radix, Gan Song, mint and Radix Curcumae [1]. 5 Functions Indications < P > Functions of clearing heart-fire, resolving phlegm, calming and lowering blood pressure [1]. Treat liver fire, dizziness, irritability, or phlegm fire, and hypertension [1].
6 Usage and dosage of Niuhuang Jiangya Pills
Honey pills, 1.6g each, 1-2 pills each time, once a day [1].
Take 1 ~ 2 pills orally once a day. After taking this medicine, the blood pressure drops to normal level. It is the unique effect of this medicine that the blood pressure can remain stable due to headache, insomnia and tinnitus. 7 Clinical research < P > Experimental research shows that the drug has antihypertensive effect on renal hypertensive rats, and its antihypertensive effect is rapid, and the antihypertensive process is mild and slow, and finally the arterial blood pressure of renal hypertensive rats can be reduced to near normal level. 8 Pharmacopoeia Standard 8.1 of Niuhuang Jiangya Pill Name
Niuhuang Jiangya Wan 8.2 Prescription
antelope horn, pearl, buffalo horn concentrated powder, artificial bezoar, borneol, radix Paeoniae Alba, Radix Codonopsis, Radix Astragali, Semen Cassiae, Ligusticum Chuanxiong, Scutellariae Radix extract, Gan Song, mint, and Radix Curcumae 8.3, except artificial ones. Grinding antelope horn file into fine powder; Pulverizing the other nine herbs including Radix Paeoniae Alba into fine powder; Grinding concentrated powder of artificial bezoar, Borneolum Syntheticum and Cornu Bubali, mixing with the above powder, sieving, and mixing. 65-75g refined honey and appropriate amount of water are used for making pills for every 1g of powder, and dried to make honey pills, or 1～12g refined honey is added for every 1g of powder to make big honey pills. 8.4 characteristics
this product is a dark brown honey pill, or a light brown green to dark brown honey pill; The gas is slightly fragrant, the taste is slightly sweet and bitter, and it has a cool feeling. 8.5 identification
(1) Take 2g of this product, cut it into pieces, add 2g of diatomite, grind it evenly, add 3ml of chloroform, perform ultrasonic treatment for 3min, filter it, and concentrate the filtrate to 2ml as the test solution. Another borneol reference substance was added with chloroform to make a solution containing .2mg per 1ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b, Pharmacopoeia, 21 Edition), 1 ~ 2 μ l of the above two solutions were absorbed, respectively, on the same silica gel G thin-layer plate, developed with cyclohexane-ethyl acetate (9: 1) as developing agent, taken out, dried, sprayed with 5% phosphomolybdic acid ethanol solution, and heated at 15℃ until the spots became clear. In the chromatogram of the test sample, the same blue spots appear in the position corresponding to the chromatogram of the control sample.
(2) Take 2g of this product, cut it into pieces, add 2g of diatomaceous earth, grind it evenly, add 3ml of methanol, perform ultrasonic treatment for 3min, filter, and concentrate the filtrate to 2ml as the test solution. Take another cholic acid reference substance and add methanol to make a solution containing 1mg per 1ml as the reference substance solution. According to the test of thin layer chromatography (Appendix ⅵ b, Pharmacopoeia, 21 Edition), 6μl of test solution and 2μl of reference solution were drawn, respectively, on the same silica gel G thin layer plate, developed with isooctane-n-butyl ether-glacial acetic acid (8: 5: 5) as developing agent, taken out, dried, sprayed with 1% phosphomolybdic acid ethanol solution, and heated to 15℃. In the chromatogram of the test sample, spots with the same color appear at the positions corresponding to the chromatogram of the control sample.
(3) Take 5g of this product, cut it into pieces, add 2g of diatomaceous earth, grind it evenly, add 3ml of diethyl ether, perform ultrasonic treatment for 15min, filter, evaporate the filtrate, and add 1ml of ethyl acetate to the residue to dissolve it, which is used as the test solution. Another 1g of Ligusticum chuanxiong Hort. was taken, and 2ml of ether was added to make a control medicinal solution by the same method. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 21 edition), 6 ~ 1μ l of the test solution and 2μl of the control medicinal material solution were absorbed, respectively, on the same silica gel G thin-layer plate, developed with cyclohexane-ethyl acetate (9: 1) as the developing agent, taken out, dried and examined under an ultraviolet lamp (365nm). In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
(4) Take 5g of this product, cut it into pieces, add 5ml of water, heat and reflux it for 2min, let it cool, centrifuge, take the supernatant, shake and extract it with water-saturated n-butanol for 3 times, 2ml each time, combine the n-butanol solutions, wash it with ammonia test solution for 2 times, discard the ammonia solution, evaporate the n-butanol solution to dryness, add 1ml of methanol to the residue to dissolve it, and take the supernatant as the test solution. Another astragaloside IV reference substance was added with methanol to make a solution containing .5mg per 1ml as the reference substance solution. According to the test of thin layer chromatography (Appendix ⅵ b, Pharmacopoeia, 21 Edition), 6 ~ 1μ l of test solution and 2μl of reference solution were absorbed, respectively, on the same silica gel G thin layer plate, and the lower layer solution of chloroform-methanol-water (13: 6: 2) which was left overnight below 1℃ was used as the developing agent, which was unfolded, taken out, dried and sprayed with 1% sulfuric acid ethanol. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the reference sample; Under the ultraviolet lamp (365nm), fluorescent spots of the same color appeared. 8.6 the inspection
shall comply with the relevant provisions under pills (appendix 1a of Pharmacopoeia I, 21 edition). 8.7 determination of content 8.7.1 radix paeoniae alba
was determined by high performance liquid chromatography (appendix ⅵ d, 21 edition pharmacopoeia). 8.7.1.1 chromatographic conditions and system applicability test < P > Octadecylsilane bonded silica gel was used as filler; Acetonitrile-water (15: 85) was used as the mobile phase. The detection wavelength is 23nm. The theoretical plate number should be not less than 3 calculated by paeoniflorin peak. Preparation of 8.7.1.2 reference substance solution
Accurately weigh a proper amount of paeoniflorin reference substance and prepare a solution containing .1mg per 1ml with dilute ethanol. Preparation of 8.7.1.3 test solution
Take this product honey pills, chop them up, take about 2g, and weigh them accurately; Or take the honey pill with weight difference, cut it into pieces, take about 2g, weigh it accurately, put it in a conical bottle with a stopper, add 5ml of water accurately, perform ultrasonic treatment for 45 minutes (power 22W, frequency 5kHz), centrifuge (rotation speed is 3rpm), accurately absorb 1ml of supernatant, add it to a polyamide column (3g, inner diameter is 15mm), and elute with water. 8.7.1.4 determination method
Accurately suck 5μl of reference solution and 5 ~ 1 μ l of test solution respectively, inject them into a liquid chromatograph, and determine.
this product contains paeoniflorin (C23H28O11), and the honey pill should not be less than .7mg； per 1g; Damiwan shall not be less than 1.12mg per pill. 8.7.2 scutellaria baicalensis Georgi extract
was determined by high performance liquid chromatography (appendix ⅵ d, Pharmacopoeia I, 21 edition). 8.7.2.1 chromatographic conditions and system applicability test < P > Octadecylsilane bonded silica gel was used as filler; Using methanol-glacial acetic acid-water (4: 1: 6) as the mobile phase; The detection wavelength is 28nm. The theoretical plate number should be not less than 4 calculated by baicalin peak. Preparation of 8.7.2.2 reference substance solution
Take a proper amount of baicalin reference substance, weigh it accurately, and make a solution containing 6μg per 1ml with dilute ethanol solution. Preparation of 8.7.2.3 test solution
Take this product honey pills, chop them up, take about 1g, and weigh them accurately; Or take the honey pill with weight difference, cut it into pieces, take about 1g, weigh it accurately, add 5ml of dilute ethanol accurately, weigh it, heat and reflux for 3min, let it cool, weigh it again, supplement the lost weight with dilute ethanol, shake it evenly, filter it, accurately absorb 5ml of continuous filtrate, put it in a 1ml volumetric flask, add dilute ethanol to the scale, and shake it evenly. 8.7.2.4 determination method
Accurately aspirate 1μl of reference solution and 1μ l of test solution respectively, inject them into liquid chromatograph, and determine.
this product contains baicalin (C21H18O11) as the extract of scutellaria baicalensis Georgi, and the honey pill should not be less than 55mg per 1g; Damiwan shall not be less than 7mg per pill. 8.8 Functions and indications < P > Clearing away heat and resolving phlegm, calming the liver and calming the nerves. Used for dizziness, headache, insomnia and restlessness caused by hyperactivity of heart and liver and excessive phlegm-heat; Hypertension with the above syndromes. 8.9 Usage and dosage < P > Oral. 2 ~ 4 honey pills once, once a day; Big honey pill 1 ~ 2 pills at a time, once a day. 8.1 note
people with diarrhea should not take it. 8.11 specifications
(1) honey pills? Every 2 pills weigh 1.3g
(2) Big honey pills? Each pill weighs 1.6g 8.12, stored < P > and sealed. Version 8.13
Chinese People's Pharmacopoeia (21 edition) 9 Niuhuangjiangya Pills Instructions 9.1 Drug Name
Niuhuangjiangya Pills 9.2 Chinese Pinyin
Niuhuang Jiangya Wan 9.3 dosage form
Shuimi Pills, each 2 pills weighs 1.3g；; Big honey pills, each weighing 1.6g g. 9.4 Character < P > Niuhuang Jiangya Pill is a dark brown honey pill or a light brown green to dark brown honey pill; The gas is slightly fragrant, the taste is slightly sweet and bitter, and it has a cool feeling. 9.5 The main components of Niuhuang Jiangya Pill are < P > antelope horn, pearl, buffalo horn concentrated powder, bezoar, borneol, realgar, cassia seed, codonopsis pilosula, astragalus root, white peony root, Ligusticum chuanxiong, Scutellaria baicalensis, Gan Song, mint and Curcuma aromatica. 9.6 Niuhuang Jiangya Pill is mainly used for clearing away heart-fire, resolving phlegm, calming the liver and calming the nerves. Used for dizziness, headache, insomnia and restlessness caused by hyperactivity of heart and liver and excessive phlegm-heat; Hypertension with the above syndromes. 9.7 Pharmacological Effects of Niuhuang Jiangya Pill
1. Niuhuang Jiangya Pill has a significant antihypertensive effect on renal hypertension model rats. The experiment is divided into three groups: modeling group, sham operation control group and administration group after modeling. After modeling, the arterial blood pressure rose to the highest value and stabilized for about 6 days. After taking Niuhuang Jiangya Pill powder, the blood pressure dropped rapidly, but the process of blood pressure reduction was gentle and slow. Finally, the arterial blood pressure of renal hypertensive rats could drop to near normal level.
2. Sedation: Niuhuang Jiangya Pill can significantly reduce the cage climbing activity of mice, indicating that Niuhuang Jiangya Pill has a certain sedative effect.
3. diuresis: the urine volume of rats fed with Niuhuang Jiangya Pill powder increased significantly, suggesting that it still has diuretic effect. 9.8 Indications of Niuhuang Jiangya Pill
1. Dizziness. Symptoms include dizziness, headache and brain swelling, red eyes and bitter taste, restlessness, insomnia and dreaminess, chest tightness and palpitation, thirst and thirst, elevated blood pressure, red tongue with yellow and greasy coating, and slippery pulse.
2. Application indications: The key point of syndrome differentiation of Niuhuang Jiangya Pill is excessive liver fire and phlegm heat. The main symptoms are dizziness, headache, restlessness, insomnia, red eyes and bitter taste, red tongue with yellow and greasy coating, and slippery pulse. 9.9 Precautions
1. Diarrhea and loose stool occasionally occur in clinic.
2. Use with caution for pregnant women.
3. Niuhuang Jiangya Pill has a strong clearing and lowering effect, so it is not suitable for patients with excess heat syndrome. 9.1 Usage and dosage of Niuhuang Jiangya Pill < P > Oral. 2 ~ 4 honey pills once, once a day; Big honey pill 1 ~ 2 pills at a time, once a day. 9.11 Expert comments