How long does it take to take dhea for premature ovarian failure? How many pills of dhea should be taken a day?
How long does it take to take dhea for premature ovarian failure? How many pills of dhea should be taken a day? How long does it take for dhea to be effective for premature ovarian failure? How many pills of dhea should be taken a day? SS
Dhea is available in 25mg and 50mg. If you must take dhea, do not exceed 50mg a day. Why is there such a strict gram requirement?
Because it will have certain side effects!
Because dhea increases androgen, DHEA has limitations and unsafeties, and the quantitative standards used by different races are difficult to control. Although DHEA can affect human hormones, the quantitative standards are different for different body types. Races also vary, so use with caution.
An article published in 2010 by Professor Margaret E. Wierman, vice president of the American Endocrine Society, completely changed the history of DHEA. He said: "We do not have any data to support the use of testosterone or DHEA alone in women. , simply supplementing DHEA has certain limitations, and the treatment effect is not ideal. Specifically, fertility is a complex system, and testosterone cannot simply solve ovarian function, cognitive decline, cardiovascular diseases, metabolic diseases, and other diseases. Sexual disorders.”
Since then, the American Endocrinology Society has joined forces with the American College of Obstetricians and Gynecologists and the American Society for Reproductive Medicine to solve the problem of endogenous and exogenous problems affecting women’s fertility in a safe way. , the European Society of Endocrinology and the International Menopause Society*** jointly appointed a working group to re-evaluate published information on various factors affecting fertility and issued treatment guidelines for the complex pregnancy repair factor DHEA AMH. Analysis of the meaning of DHEA AMH: DHEA balances maternal hormone levels before conception, and AMH increases the reserve function of eggs.
DHEAAAMH is different from simple DHEA, but a collection of more than 30 patented energy factors. They can intensively and urgently raise eggs, raise nests and other energy factors to maintain fertility problems. It is known in Europe as an energy factor. Considered to be a source of energy for assisted pregnancy, the UK, Germany and many other European countries have done a lot of research on DHEAAMH. At present, most DHEAAMH in our country is imported from abroad. In recent years, the use of DHEAAMH for patients with low ovarian function has been recognized by many countries. According to surveys, about 1/3 of fertility centers around the world have begun to add DHEAAMH to patients with low ovarian function.
Compound pregnancy repair factor DHEA AMH - multi-system treatment guide
Natural pregnancy\test tube - how to have a healthy egg and embryo implantation environment
Analysis of the meaning of DHEA AMH: DHEA balances maternal hormone levels before conception, and AMH increases the reserve function of eggs.
Female conception is the physiological process in which sperm and eggs meet and reach the uterus:
( 1) First, the internal and external reproductive systems develop normally to ensure normal sexual life. The fallopian tubes have good functions of picking up eggs, transporting eggs, fertilizing and transporting fertilized eggs to the uterine cavity.
(2) The function of the female endocrine axis hypothalamus-pituitary-ovary is normal, mature follicles are discharged, and the corpus luteum is formed and functions well.
(3) The cyclic changes in the proliferative phase and secretory phase of the endometrium are conducive to the implantation of the fertilized egg. Abnormalities in any of the above steps can lead to pregnancy disorders.
Female fertility disorders are composed of many factors, which may coexist in most cases, so we need to address not only the primary cause, but also other secondary causes. Only in this way can we get one step closer to the goal of pregnancy.
A questionnaire from the American Society of Endocrinology: This survey *** obtained 432 valid questionnaires, including 216 from female infertile patients and 216 from women with normal fertility.
The analysis results are as follows: Cause composition ratio analysis: The main causes of female infertility are fallopian tube diseases (41.3), ovarian diseases (32.4), immune infertility diseases (8.3), unexplained diseases (5.1), Uterine diseases (4.6), vaginal inflammation (4.6), endocrine diseases (2.3), genetic diseases (1.4).
The main cause of fallopian tube infertility is fallopian tube obstruction. The main causative factors are: sexually transmitted diseases, gynecological inflammation (non-specific), and endometrial injury.
Ovarian infertility is mainly due to ovarian failure and infertility. The main causes are: premature ovarian failure, abnormal ovarian function, polycystic ovary syndrome, ovarian chocolate cysts, and gynecological inflammation (non-specific).
Compound pregnancy preparation repair factor DHEA AMH—premature ovarian failure improvement system
Premature ovarian failure improvement system—provides back-up guarantee for oocyte quality
Analysis of the significance of DHEA AMH : DHEA balances the mother's hormone levels before conception, and AMH increases the reserve function of eggs.
In this survey, premature ovarian failure and abnormal ovarian function caused infertility in infertility 0. 1, and premature ovarian failure in clinical practice Manifested by higher levels of gonadotropin FSH and the occurrence of amenorrhea. The disease of premature ovarian failure seriously affects women's psychological status and fertility, causes endocrine disorders, and greatly reduces the probability of women getting pregnant.
When a woman is born, there are the most follicles in the ovary, about 2 million, but only 400-500 can eventually mature, and most of them will die with age. The manifested phenomenon is that ovarian function decreases, ovulation function disappears, and fertility function decreases. A normal woman has 12 eggs in her ovaries at the age of 30, but only 3 by the time she is 40. In addition to the decline in the function of egg cells with age, when women approach menopause, their menstrual cycles will become more disordered, and the endometrium will become thinner, making it less suitable for fertilized eggs to implant. At the same time, vaginal secretions decrease and vaginal dryness is not conducive to menopause. Entry of sperm.
Another benefit of DHEAAMH is the unexpectedly high pregnancy rate in women, especially in women with diminished ovarian function. Supplementation with DHEAAMH has also been associated with increased cumulative pregnancy rates and shortened interpregnancy intervals, and there is evidence of reduced ovarian function entering into the evaluation and treatment of infertility disorders.
A case-control study was conducted over a 10-year period from 2005 to 2015 in 190 women over the age of 30 with diminished ovarian function. The study group included 89 patients with an average age of about 41.6 years who supplemented with about 75 mg of oral micronized DHEA daily for up to four months before entering IVF. The control group consisted of 101 patients with a mean age of approximately 40.0 years who were treated for infertility without DHEAAMH. The primary outcome was clinical pregnancy after the patient's initial presentation.
Ovarian stimulation was identical in the study and control groups and consisted of microdose agonist stimulation followed by maximal dose gonadotropin stimulation using approximately 300-450 IU of FSH and approximately 150 IU of HMG. Study patients continued to receive DHEAAMH until a positive pregnancy test was obtained or until the patient discontinued treatment.
Using the risk model developed, the proportional risk of pregnancy in women using DHEAAMH was compared with a control group. As a result, the cumulative clinical pregnancy rate was significantly higher in the study group (28 out of 25 pregnancies in 89 patients and 11 out of 10 pregnancies in 101 patients); specifically, approximately 58 of the patients who received DHEAAMH achieved clinical pregnancy, Approximately 11 of the patients who did not receive DHEAAMH achieved clinical pregnancy. Therefore, treatment with DHEAAMH increased the percentage of clinical pregnancies by approximately 130 to approximately 180.
As clinical pregnancy rates increased, the miscarriage rate decreased after DHEAAMH treatment among women in this study, with an average age of approximately 31.6 years. Clinical data provide evidence that supplementation with DHEAAMH increases spontaneous pregnancy rates, in vitro pregnancy rates, cumulative pregnancy rates, and shortens the time between pregnancies.
Compound pregnancy preparation repair factor DHEA AMH - egg quality and quantity regulation system
Egg quality and quantity regulation system - supplement ovarian nutrition and repair ovarian function
Analysis of the significance of DHEA AMH: DHEA balances maternal hormone levels before conception, and AMH increases the reserve function of eggs.
The age of first childbirth is getting later and later, and more and more older women are considering having children. However, older women The decline in fertility is an indisputable fact, so that the number of patients with reduced ovarian reserve function is increasing year by year, which makes the proportion of patients who undergo controlled super-ovulation stimulation during in vitro fertilization and embryo transfer significantly increase. It is estimated that 5 The -18 test tube cycle ended due to low ovarian response. Poor ovarian response will lead to low follicle recruitment, low egg retrieval, especially low number of high-quality eggs, and high cycle cancellation rate, so that the pregnancy rate will be seriously reduced, which has become one of the problems in the field of assisted reproduction.
Primordial follicles are the basic reproductive functional units that store eggs in female mammals. Research in recent years has shown that stem cells can be induced to develop into mature female germ cells and that there is a phenomenon of primordial follicle bank renewal in the ovary. However, both involve the same issue, namely the formation and development mechanism of primordial follicles. Many researchers have conducted extensive exploration into the formation and development process of primordial follicles. Scholars have found that the formation and development process of primordial follicles require the influence of various growth factors or hormones or some signaling pathways.
DHEAAAMH multi-trophic growth factor is composed of three major growth systems. Many research results have confirmed that DHEAAMH is helpful in regulating the proliferation and differentiation activities of primary follicles and secondary follicles. Studies have confirmed that it can promote the proliferation and differentiation of granulosa cells and play an important regulatory role in the development of follicles. DHEAAMH can be a strong cell repair factor that promotes the division, proliferation and differentiation of granulosa cells and the development of oocytes. It is well established that DHEAAMH supplementation increases peripheral blood estrogen levels in women while simultaneously decreasing progesterone levels. Researchers measured estrogen and progesterone levels on the ovaries of different women and detected OSE proliferation. The results showed that estrogen promotes OSE proliferation and differentiation, while progesterone inhibits OSE proliferation and differentiation.
External supplementation is required 3-4 months before ovulation induction. Increasing DHEAAMH can increase the recruitment of follicles and promote follicle growth and development. DHEAAMH promotes the secretion of insulin-like growth factors, thereby amplifying the effect of gonadotropins and improving ovarian response. sex. Studies have found that when women take DHEAAMH before an ovulation induction cycle, their IGF-1 levels show an instant increase after 8 weeks, and androgen levels in the follicles increase, promoting the secretion of AMH and inhibin by granulosa cells. DHEAAMH can induce the production of FSH receptors in granulosa cells, increase the sensitivity of granulosa cells to FSH, and promote estrogen synthesis and follicle development. Studies have shown that the peak period of DHEAAMH action coincides with the cycle of follicle recruitment, which confirms the promoting effect of DHEAAMH on follicle recruitment.
Compound pregnancy preparation and repair factor DHEA AMH—polycystic pregnancy nurturing system
Polycystic pregnancy nurturing system—cultivating high-quality follicles for polycystic mothers
In this survey , Polycystic ovarian infertility accounts for infertility in ovarian ovulation disorder infertility. 1. It is the main cause of infertility in ovarian infertility, which is slightly lower than the data reported in the relevant literature, but it is still the first cause of infertility in ovarian infertility.
Polycystic disease mainly manifests as hyperandrogenism, ovarian dysfunction and polycystic ovary morphology, and is related to insulin resistance, obesity, oxidative stress and chronic low-grade inflammation. Ovarian dysfunction remains a cardinal feature of this syndrome and a major cause of anovulatory infertility.
The incidence of this disease is about 10-13% of women of childbearing age, and as high as 30-60% of those with ovulatory disorders.
In women with polycystic anovulation, the method is still to change lifestyle (lose weight and exercise) and use clomiphene citrate and letrozole to induce ovulation. Other recognized options include surgical ovarian wedge resection, laparoscopic ovarian drilling, and metformin, bromocriptine, and others.
Research has found that the increased macrophages and lymphocytes in the ovaries of polycystic women can secrete a variety of cytokines to induce granulosa cell apoptosis, thereby hindering the production of dominant follicles. DHEA AMH's more than 30 kinds of brood nutrients are mainly derived from plant cell membranes and cell walls of higher plants in nature. DHEA AMH can be used as an effective free radical scavenger to balance the balance of oxidation and antioxidant in the cell system and inhibit intracellular activity. The formation of oxygen. DHEA AMH can inhibit lipopolysaccharide-induced macrophage inflammatory response and reduce the expression of TNF-α and IL-6. According to the above research results, DHEA AMH also has a certain effect on improving inflammation and reactive oxygen species levels in polycystic patients.
In the granulosa cells of polycystic women undergoing in vitro fertilization, excessive production of reactive oxygen species was closely related to abnormal cell morphology, reduced MMPs, and increased levels of DNA fragmentation. The above studies all suggest that inflammation and oxidative stress in granulosa cells are likely to be one of the important causes of abnormal multicystic follicle development, and DHEA AMH can reduce inflammation and oxidative stress in granulosa cells by improving the function of granulosa cells, thus increasing egg production. The quality of the mother cell. Improve inflammation and oxidative stress in granulosa cells of polycystic ovary.