After receiving the notice of patent examination opinions (by mail), reply directly to the State Patent Office by e-mail, without going through the local intellectual property office?

Reply directly to the State Patent Office. Because the local intellectual property office only receives your patent documents on behalf of the State Patent Office and forwards them to the State Patent Office.

According to the provisions of the Review Guide, the reply period of the first review notice is four months, and the reply period of the second review notice is two months. Please pay attention to the reply period and ensure that the reply is submitted within the specified time limit. If the inventor thinks that it is really difficult to reply within the time limit specified in the notice, he may submit a written request to extend the time limit before the expiration date of the reply period 15, requesting the Patent Office to extend the specified reply period.