1. General symptoms: pale and gray face, general weakness, and weight loss. 2. Gastrointestinal manifestations: This is the earliest and most prominent manifestation of this disease. Anorexia, abdominal discomfort, followed by nausea, vomiting, diarrhea, glossitis, oral ulcers, urine-smelling breath, and later gastrointestinal bleeding, melena and hematemesis may occur. 3. Mental and nervous system manifestations: headache, dizziness, confusion, indifferent expression, drowsiness, lethargy, and even coma. Restlessness, muscle tremors, twitching, and convulsions are also common in the later stages. 4. Cardiovascular system manifestations: elevated blood pressure and common arrhythmia; fibrinous pericarditis and heart failure may still occur in the late stage. 5. Hematopoietic system manifestations: severe anemia, and bleeding symptoms may still occur in the late stage. 6. Respiratory system manifestations: Deep and long breathing during acidosis. In the late stage, it can cause uremic bronchitis, pneumonia and pleurisy. 7. Skin manifestations: dull, dry and flaky skin. After urea is excreted from the sweat glands, it can condense into white urea cream, which can also irritate the skin and cause itching. 8. Symptoms caused by metabolic acidosis and acid-base balance imbalance: ① Dehydration or edema. ② Metabolic acidosis. ③ Hyponatremia and sodium retention. ④ Hypocalcemia and hyperphosphatemia: Hyperphosphatemia and hypocalcemia can stimulate the parathyroid glands, causing secondary hyperparathyroidism, leading to bone decalcification. It can cause renal rickets in young patients and adult patients. Causes uremic bone disease. ⑤ Hypokalemia and hyperkalemia; Hypokalemia and hyperkalemia are common causes of arrhythmia and sudden death in uremia. During the uremic azotemia stage, the kidney function damage of patients is already quite serious. If the patients do not receive effective treatment during this stage, many patients will develop into late stages of uremia, which will not only greatly increase the difficulty of treatment. , the cost will also increase significantly. Symptoms that occur in the uremic azotemia stage can indirectly reflect the current condition of the patient. When these conditions occur that have obviously threatened the patient's health and safety, it is important that the uremic patient seek medical treatment in time and do not delay the disease to its end. final stage.