Excessive use can cause adverse reactions: daily use of 1 ~ 4g can cause diarrhea, rash, gastric acid increase, gastric reflux, urinary calculi, increased excretion of oxalate and urate in urine, deep venous thrombosis, intravascular hemolysis or coagulation, etc. Sometimes, it will lead to the decline of phagocytosis of white blood cells.
When the daily dose exceeds 5g, it can lead to hemolysis, and in severe cases, it can be fatal. When pregnant women take large doses, infants may develop scurvy.
Extended data:
Oxalic acid is the final important product of vitamin C catabolism in the body. Oxaliuria may occur after long-term use, leading to urinary calculi. ?
The nutritional deficiency caused by long-term vitamin C deficiency is called scurvy, which is characterized by swelling and bleeding of gums, petechiae and ecchymosis on the skin, and massive bleeding all over the body.
As early as16th century, the prevalence of this deficiency has been observed. Large-scale vitamin C deficiency is rare, but it still occurs in infants and the elderly. Scurvy is rare in adults, but those who restrict their diet or do not eat fruits and vegetables for a long time often lead to vitamin C deficiency.
References:
VC- Baidu encyclopedia