Which hospital in Chengdu is good for IVF? In vivo fertilization, IVF needs artificial in vitro fertilization to get eggs and sperm, and then the embryo is transplanted into the uterus. The chance of success is greater than that of IVF. Go to a professional local regular hospital for examination and treatment. In vitro fertilization, usually tubal blockage, can be chosen if the treatment is not good. Artificial conception, if the man's sperm quality is not high, can generally choose. Of course, this needs to be chosen according to the situation of both husband and wife.
IVF, also known as in vitro fertilization-embryo transfer, refers to a technology that takes eggs and sperm out of the human body by artificial means, fertilizes them in vitro, develops into embryos, and then transplants them back into the mother's uterus to achieve the purpose of pregnancy.
We must know what IVF is. Children who don't really grow up in test tubes live in their mothers' bodies. At present, most people are only in a preliminary understanding of IVF, and the deeper understanding of this new technology is not so comprehensive and profound. Let's make a systematic introduction to IVF. IVF is a new technology to assist pregnancy, which is not mature in China at present. Therefore, experts suggest that couples who can't have children after receiving scientific treatment can consider the last step: doing IVF. In other words, this is not a relatively safe and reliable means of assisting pregnancy. Of course, if we consider IVF transplantation, we should also consider the possibility of its failure and make corresponding preparations. IVF is also called embryo transfer after in vitro fertilization. With the help of endoscope or under the guidance of B-ultrasound, it is a new technology that mature eggs and sperm are taken out and cultured in vitro, so that eggs can be fertilized and developed into embryos, and then sent to women's uterus with the help of endoscope to achieve the purpose of pregnancy. However, according to authoritative statistics, because IVF technology is still in an immature stage, the success rate is low, the cost is high, the process is complex, and it is only a means of assisting pregnancy. Most infertile patients still insist on choosing safe treatment technology and choosing natural delivery.
IVF Process Generally speaking, the birth of IVF is divided into the following steps:
1, ovulation induction therapy
Because not every egg can be fertilized and not every fertilized egg can develop into a viable embryo, it is necessary to obtain multiple eggs from women to ensure that embryos can be transplanted, which requires ovulation induction treatment for women.
There are many ovulation induction schemes, including standard long scheme, short scheme and antagonistic scheme. Long regimen refers to the application of GnRH agonist in luteal phase of the previous cycle, short regimen refers to the application of GnRH agonist on the second day of menstrual cycle, and antagonist regimen refers to the application of gonadotropin first, and then GnRH antagonist after the follicle grows to a certain extent. The purpose of using GnRH agonists or antagonists is to prevent spontaneous ovulation of eggs before egg retrieval.
Generally speaking, the success rate of long programs is the highest, but not all used women are suitable for long programs. The ovulation induction plan must be formulated according to each person's specific situation, which is the so-called "individualized" treatment.
Before entering the IVF cycle, in most cases, in order to inhibit ovulation, women will take birth control pills in the previous cycle, which can avoid the influence of GnRH agonists on the fetus during natural cycle pregnancy (which may lead to abortion). In addition, for people with irregular menstruation, the use of contraceptives can easily determine the time to promote ovulation. In addition, the use of contraceptives can also prevent the formation of ovarian physiological cysts, which is conducive to ovulation induction treatment.
On the second day of menstrual cycle, or after the inhibition of GnRH agonist is satisfactory (the results of reproductive hormone and ultrasound examination of uterus and ovary meet the requirements), women begin to use ovulation-promoting drugs. Doctors judge the growth of follicles according to the results of ultrasonic monitoring and serum hormone determination, and decide whether it is necessary to adjust the dose of ovulation induction drugs. When the follicle matures, hCG is injected to promote the final maturation of the egg. Eggs are usually taken 36-38 hours after hCG injection.
Step 2 get eggs
Under the guidance of B-ultrasound, the doctor used a special needle to puncture mature follicles through vagina and suck out eggs. Egg retrieval is usually carried out under intravenous anesthesia, so women will not feel the pain caused by puncture.
3. In vitro fertilization
Acquisition of sperm: women take eggs and men take sperm. After the semen goes through a special cleaning process, the sperm and eggs are put into a special culture medium for natural combination. This is called conventional fertilization.
4. Embryo transfer
A few days after fertilization, the best embryo was transplanted into the mother's uterus through the cervix with a very thin embryo transfer tube. According to the age, embryo quality and the outcome of previous IVF, the number of embryos to be transplanted is determined, usually 2-3 embryos are transplanted. In recent years, in order to reduce the multiple pregnancy rate, some centers choose single embryo transfer or transfer at most two embryos.
Because the embryo transfer tube is very thin and the doctor moves lightly, patients usually don't have any pain.
5, corpus luteum support
Due to the application of GnRH agonists/antagonists and ovulation drugs, as well as the loss of follicular granulosa cells caused by egg retrieval, women usually have insufficient luteal function during the egg retrieval cycle, so progesterone and/or chorionic gonadotropin are needed for luteal supplementation/support. If you are not pregnant, stop using progesterone and wait for menstrual cramps. If you are pregnant, continue to use progesterone, usually 3 weeks after B-ultrasound sees the fetal heart.
6. Determination of pregnancy
Serum HCG was measured 14 days after embryo transfer to determine whether pregnant or not. Serum HCG was measured again 2 1 day after embryo transfer to understand the embryo development. Transvaginal ultrasound was performed 30 days after embryo transfer to determine whether there was intrauterine pregnancy and fetal heart beat.