On August 26th, 20021,Aunt Chen, a patient with diffuse large B-cell lymphoma (DLBCL), went through the discharge formalities from the hematology department of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine.
The vice president of Ruijin Hospital and professor of hematology said that Aunt Chen was the first patient in China who was assessed as complete remission (CR) after receiving CAR-T drug infusion treatment. Her condition has increased the confidence of other patients with relapsed or refractory large B-cell lymphoma to receive CAR-T treatment.
Aunt Chen is an elderly patient with recurrent diffuse large B-cell lymphoma. 2065438+diagnosed in July 2009. She relapsed after first-line treatment, and the second-line effect was not good. In the hematology department of Ruijin Hospital, experts consider the mutation of TP53 gene, and the prognosis of conventional chemotherapy or targeted therapy is poor.
On June 22nd this year, the first CAR-T cell therapy drug in China was approved for marketing. For Aunt Chen, there is finally a glimmer of hope for life. After full communication and discussion with patients' families, Zhao Weili's team decided to carry out the latest CAR-T cell therapy. On June 28th, Xu, the deputy chief physician of the team, wrote a prescription for the patient. On June 30th, the nursing team of the National Center for Translational Medicine collected cells for Aunt Chen.
After intense waiting, CAR-T cells were successfully transfused on August 2nd. At present, the curative effect of PET-CT is evaluated for the first time. At the same time, after receiving CAR-T treatment, under the careful care of the medical team, Aunt Chen's physical condition is also very good, and her life is full of joy and miracles again.
The hematology department of Ruijin Hospital has rich experience in the diagnosis and treatment of lymphoma, and advocates standardized, accurate and humanized treatment. In recent ten years, under the leadership of Zhao Weili, the team established the largest human lymphoma biological sample bank in China and the molecular typing gene profile of DLBCL in China.
It provides detailed research data for the accurate diagnosis and treatment of lymphoma in China. In the process of treating Aunt Chen, we can adjust the corresponding treatment plan in time according to her illness progress and physical condition.
The above contents refer to Baidu Encyclopedia-Ruijin Hospital.