Pharmacokinetics of Fan Minbu

Animal experiments show that rats take [sup] 57 [/sup] Co-CH3B12 (25 μ g? After 72 hours (kg [sup]- 1 [/sup]), the concentration in kidney, adrenal gland, pancreas, liver and stomach was higher, and the concentration in muscle, testis and brain nerve was lower. Mainly excreted through feces and urine. This product can be absorbed directly by oral administration without metabolic enzyme transformation. Healthy people take this product 1.5mg orally once, and the peak blood concentration is 3.6 hours after administration, and the maximum blood concentration is 972pg? Ml[sup]- 1[/sup], with a half-life of 12.5 hours. Eight hours after administration, the total excretion of B 12 in urine is 40% ~ 80% of that in 24 hours after administration.