Excessive stimulation of gonadotropin will accelerate follicular atresia, cause excessive consumption of follicles, and affect follicular maturation and excretion, so women will be infertile.
Second, infection.
Viral mumps in women's childhood can also cause serious ovarian damage in the early stage. Moreover, serious infections, such as bilateral fallopian tubes and ovarian abscesses, will destroy ovarian tissue and lead to premature ovarian failure.
Third, immune factors.
Premature ovarian failure is often complicated with thyroiditis, rheumatoid arthritis and systemic lupus erythematosus. In addition, there are anti-ovarian antibodies in patients' peripheral blood. After the antibody binds to the corresponding cells in the follicle, it will damage the follicle, lead to ovarian dysfunction and lead to female infertility.