Technical Innovation of Jiangsu Lianhuan Pharmaceutical Co., Ltd.

With strong R&D capability, it invests nearly 10 million yuan in new product research and development every year, and researches, develops, puts into production and reserves a batch of new products every year. Up to now, more than one national-level new drug and new drug imitation 10 have been developed, including national first-class new drugs. These new drugs have the characteristics of high technology content, some products fill the domestic gap, leading products have independent intellectual property rights, and raw materials and preparations are jointly developed and produced. Liu Chuan, the company's leading product, is the first effective drug to treat benign prostatic hyperplasia in China. /kloc-0 was awarded the national first-class certificate of new drugs in August, 1999, and was awarded as the outstanding scientific and technological achievement of the ninth five-year plan by the Ministry of Science and Technology, the State Planning Commission and the State Economic and Trade Commission in February, 2000, and was commended by the Ministry of Science and Technology, the Ministry of Commerce and the General Administration of Quality Supervision, Inspection and Quarantine in July, 2004. Since its establishment, the company has obtained non-patented technology as the only manufacturer of this drug, enjoying the exclusive right to 12 years. Apropril and its tablets are safe and effective drugs for the treatment of benign prostatic hyperplasia, which can obviously improve the micturition symptoms of patients with benign prostatic hyperplasia, reduce prostate volume and increase urine flow. The efficacy of epristeride tablets is better than finasteride, which can be achieved after taking it for two months. The drug has no serious adverse reactions, and the incidence of adverse reactions related to the drug is low, so it is suitable for long-term application in the elderly. From June 2008 to October 2008 10, the company successfully developed the sustained-release preparation (tablet) of epristeride, and won the national invention patent and the silver award in the 6th China International Invention Exhibition. The medicine can maintain the drug concentration, control the drug release rate, maintain the effective blood concentration in vivo, improve the curative effect, reduce the times of taking medicine, and is convenient to take and carry. Mindy (Terfenadine Tablets), the company's antiallergic drug, successfully overcame the drowsiness reaction of traditional drugs and was the first non-sedative antiallergic drug in China. Terfenadine granules are especially suitable for people and children who have difficulty swallowing tablets. This product has won the Gold Award of National Science and Technology Expo and the Golden Bull Award of Jiangsu New Product. Cetirizine hydrochloride and its combination (Cetirizine hydrochloride tablets), Ebastine and Sudi (Ebastine tablets) are the second and third generation non-sedative antiallergic drugs. Sudi (Ebastine Tablets) has the characteristics of strong efficacy, durability and safety. In June 2005, it was recognized as a national key new product by the Ministry of Science and Technology, the Ministry of Commerce, the General Administration of Quality Supervision, Inspection and Quarantine and the State Environmental Protection Administration. Felodipine tablets is a new calcium antagonist, which can selectively relax arterioles, improve cardiac and renal functions, and widely meet the treatment needs of various hypertensive patients. June 5438+February 2008 was recognized as a high-tech product by the Science and Technology Department of Jiangsu Province. Zheng Zhi (Simvastatin Tablets) is suitable for hypercholesterolemia and coronary heart disease, and its superior safety is suitable for long-term use. Danazol capsules produced by the company are the first choice for the treatment of endometriosis to fill the gap in China, and have won the Golden Bull Award for new products in Jiangsu Province and the gold medal in the national disease resistance competition. Danazol suppository changes the route of administration, directly acts on the affected part, takes effect quickly, and the daily dosage is only112 of the capsule, with minimal adverse reactions. This is a new dosage form of this product. The compound preparation produced by the company consists of metformin hydrochloride and gliclazide. The mechanism of action of the two drugs is complementary, and the dosage is lower than that of the two drugs alone, so the side effects are greatly reduced, which is beneficial to control the blood sugar level of diabetic patients. Balofloxacin tablets produced by the company have strong antibacterial activity, and the antibacterial activity in vitro is 2 ~ 24 times that of ciprofloxacin and ofloxacin, and the activity of staphylococcus sensitive to fluoroquinolones is 4 times stronger than that of ofloxacin and ciprofloxacin. Balofloxacin has good tolerance and few adverse reactions, and has no effect on the central nervous system. Lianhuan Youding (Sertraline Hydrochloride Capsule) produced by the company is used to treat depression, including depression with anxiety, manic history or not, and obsessive-compulsive disorder. The drug has high action intensity, which is 200 times that of amitriptyline and 36 times that of fluoxetine. It is safe and has little clinical antidepressant effect after being metabolized into norsertraline in vivo.