Two kinds of inactivated swine influenza virus H 1N 1 subtype declared by six units including Huazhong Agricultural University are new veterinary drugs, and now a new veterinary drug registration certificate is issued.
It is understood that the inactivated vaccine of swine influenza virus H 1N 1 subtype (TJ strain) is the first inactivated vaccine to prevent and control swine influenza virus in China. Developed jointly by Huazhong Agricultural University, Wuhan Keqian Animal Biological Products Co., Ltd., Wuhan Zhong Bo Biological Co., Ltd. and Zhongmu Industrial Co., Ltd., it was recently approved as a second-class new veterinary drug by the Ministry of Agriculture.
According to the decision of WHO, swine flu was renamed as influenza A (H 1N 1), while the Ministry of Health of China called it influenza A (H 1N 1) according to the convention in China, in case of misunderstanding.
Prevention and control of H 1N 1 influenza is of great significance to human health and safety.
According to some data, among the developed swine influenza vaccines, univalent or bivalent inactivated swine influenza viruses of H 1NI and H3N2 subtypes are the most mature for production.
Its form is mostly oil adjuvant vaccine, and the inactivator is generally formaldehyde or BEI.
According to reports, the inactivated swine flu vaccine can effectively protect weaned piglets and breeding pigs against SI, with the morbidity reduced by 30%-70% and the mortality reduced by 60%-87%.
At present, this kind of vaccine has been commercialized in many countries in Europe and America, such as Intel's END-FLUENCE (including IMUEN) and END FLUENCE (including microsoldiluvacforte), Pfizer's FluSure, Schering-Plough Animal Health Company's MaxiVac-FIu, MaxiVacExcell3 and so on.
Domestic South China Agricultural University, Harbin Veterinary Research Institute and other units have also done a lot of work in the development of inactivated swine flu oil emulsion vaccine.
Although SlVinactivatedvaccines have the advantages of safety, high efficiency, low production cost and long duration of effective antibodies, it also has some disadvantages, such as slow antibody production, weak ability to induce cellular immunity and strong stress response.
In particular, most vaccine strains come from epidemic strains. Once the virus is leaked in the process of vaccine preparation, it will easily cause environmental pollution and induce a new epidemic.
To this end, scientists are still exploring and developing new swine flu vaccines.