How many vaccine manufacturers are there?

At present, there are 33 large-scale vaccine production enterprises in China, mainly producing 49 varieties, which can prevent 26 infectious diseases. Among them, the output of vaccines used to prevent common pediatric diseases such as hepatitis B, polio, measles, whooping cough, diphtheria and tetanus reached 500 million people.

Major domestic vaccine varieties and manufacturers:

I. Name of vaccine production enterprise

1, bacteria, toxoid

Chengdu Institute of BCG and Shanghai Institute of BCG.

Cell-free DTP vaccine Lanzhou suo

Wuhan Institute, Changchun Institute, Chengdu Institute and GSK adsorbed cell-free DTP combined vaccine.

Combined vaccine of pertussis, diphtheria and tetanus adsorbed by Wuhan Institute, Chengdu Institute and Shanghai Institute.

Oral bivalent dysentery live vaccine Lanzhou Institute

Changchun Institute of Tetanus Vaccine Adsorption, Tiantan Institute of Biology, Shanghai Institute

Shanghai Leptospira Vaccine Institute and Wuhan Institute.

Tetanus vaccine in Wuhan, Chengdu, Shanghai and Changchun.

Pertussis vaccine Lanzhou suo

Lanzhou Institute and Shanghai Diphtheria Vaccine Adsorption Institute.

Lanzhou adsorption pertussis and diphtheria joint vaccine institute

Shanghai Institute of Diphtheria and Tetanus Vaccine, Wuhan Institute, Tiantan Biology

Diphtheria and tetanus toxoid Lanzhou suo

2. Attenuation

Changchun Institute of Freeze-dried Live Attenuated Hepatitis A Vaccine, Zhejiang Pukang Institute, Kunming Institute of China Academy of Medical Sciences.

Lanzhou Institute of Oral Rotavirus Attenuated Vaccine

Oral bivalent live vaccine for dysentery of Freund's disease and Sonne's disease in Lanzhou Institute.

Live attenuated measles vaccine provided by Lanzhou Institute, Shanghai Institute, Wuhan Institute and Tiantan Biology.

Live attenuated rubella vaccine from Lanzhou Institute, Shanghai Institute and Tiantan Biology.

Lanzhou institute of live attenuated Japanese encephalitis vaccine

Live attenuated mumps vaccines from Lanzhou Institute, Shanghai Institute, Wuhan Institute and Zhejiang Weixin Institute.

Shanghai Institute and Wuhan Institute jointly attenuated measles and mumps live vaccine.

Biological study on the Temple of Heaven of measles and rubella combined with attenuated live vaccine

Ma Haifeng joint attenuated live vaccine Tiantan Bio and GSK.

Live attenuated varicella vaccine produced by Shanghai Institute, Changchun Institute and GSK.

Lanzhou Institute of Live Anthrax Vaccine provides vaccines for people with skin scratches.

Lanzhou Brucella Live Vaccine Research Institute is used by people with scratches on their skin.

Lanzhou skin scratch plague live vaccine institute

Live attenuated polio vaccine from Kunming Institute of Tiantan Biomedical Research Institute.

Live attenuated Japanese encephalitis vaccine from Lanzhou Institute, Chengdu Institute and Wuhan Institute.

Biology of the Temple of Heaven of Live Attenuated Yellow Fever Vaccine

3. Passivation

Lanzhou Institute and Shanghai Institute of Purified Vaccine of Hemorrhagic Fever with Renal Syndrome I.

Bivalent inactivated vaccine for hemorrhagic fever with renal syndrome Changchun Institute

Epidemic hemorrhagic fever bivalent vaccine Lanzhou suo

Lanzhou Institute and Changchun Institute of Inactivated Influenza Vaccine

Changchun Institute, Lanzhou Institute, Beijing Kexing, Zhejiang Tianyuan, GSK, Hualan Bio.

Influenza A H 1N 1 Split Vaccine Tiantan Biology and Hualan Biology

Freeze-dried human rabies vaccine (Vero cells) Changchun Institute, Lanzhou Institute, Liaoning Chengda, Jingang Andy, Rong 'an

Changchun forest encephalitis inactivated vaccine institute

Inactivated Japanese encephalitis vaccine in Lanzhou, Changchun and Shanghai.

Inactivated Japanese encephalitis vaccine (Vero cells) Liaoning Chengda, Tiantan biological

Inactivated hepatitis A vaccine Beijing Kexing, Kunming Institute of China Academy of Medical Sciences, GSK, Bernard Biotechnology.

Freeze-dried human rabies vaccine (hamster kidney cells) Lanzhou Institute, Wuhan Institute, Henan Puxin Bio.

Sanofi Pasteur inactivated polio vaccine

4. Subunit

Influenza subunit vaccine Tasly, Novartis, Neptune Intelon, Solvay Pharmaceutical.

5. Polysaccharide vaccine

Lanzhou research institute, Chengdu research institute, Wuhan research institute, Shanghai research institute, Tiantan biology institute of typhoid Vi polysaccharide vaccine

Group A meningococcal polysaccharide vaccine Tiantan Biology, Shanghai Institute and Wuhan Institute

Lanzhou Institute of A+C meningococcal polysaccharide vaccine, Zhejiang Tianyuan, Sanofi Pasteur

ACYW 135 meningococcal polysaccharide vaccine Hualan Bio, zhifei Bio, Zhejiang Tianyuan

Haemophilus influenzae B vaccine watson biological, GlaxoSmithKline, Novartis, Merck, Sanofi Pasteur.

23-valent pneumococcal polysaccharide vaccine Sanofi Pasteur and Chengdu Institute

6, combined with vaccine

Lanzhou Institute of Haemophilus influenzae B conjugate vaccine, GlaxoSmithKline, Sanofi Pasteur, watson biological and Novartis.

A+C combined meningococcal vaccines watson biological, zhifei Bio and Luoyi Bio.

Seven-valent pneumococcal conjugate vaccine Pfizer

7. Genetic engineering

Recombinant hepatitis B vaccine (CHO cells) Changchun Institute, Lanzhou Institute, Wuhan Institute, Huabei Pharmaceutical, Beijing Walton.

Recombinant hepatitis B vaccine (Saccharomyces cerevisiae) Tiantan Bio, Shenzhen Kangtai, GlaxoSmithKline

Recombinant Hepatitis B Vaccine (Hansen Yeast) Dalian Hanxin and Hualan Bio

Combined hepatitis A and hepatitis B vaccine

Major domestic second-class vaccine enterprises and products:

Mesogenic groups: Hib binding, influenza, rabies (hamster kidney cells), rabies (vero cells), typhoid Vi polysaccharide, group A epidemic cerebrospinal meningitis, and group A+C epidemic cerebrospinal meningitis.

Polysaccharide vaccine, attenuated varicella, a planned immunization vaccine.

Tiantan creatures: recombinant hepatitis B (yeast), polio, measles, leprosy, measles, Japanese encephalitis (Vero cells), influenza,

Attenuated DTP and varicella vaccine

Beijing Kexing: Inactivated hepatitis A vaccine, combined hepatitis A and hepatitis B vaccine, inactivated seasonal influenza vaccine and epidemic influenza vaccine.

Hualan biology: seasonal influenza, influenza A, tetravalent meningitis, recombinant hepatitis B (Hansenula)

Adult biology: freeze-dried rabies vaccine and inactivated vaccine for human use.

Tasly: influenza subunit vaccine

Neptune Intelon: rabies and influenza subunit vaccine (unlisted)

Zhifei, Chongqing: independent product A+C meningococcal polysaccharide binder, A+C+W 135+Y meningococcal polysaccharide, attenuated hepatitis A, main product Hib.

Dalian Hanxin: recombinant hepatitis B (Hansenula) and rabies vaccine for human use (hamster kidney cells)

Tianyuan, Zhejiang: influenza cracking, hemorrhagic fever inactivation and JE purification vaccine.

Shen Yan, Jiangsu: split vaccines for tracheitis, furuncle, rabies (vero cells) and influenza.

Yunnan Watson: Hib conjugate vaccine, A+C meningococcal polysaccharide conjugate vaccine.

Overview of some second-class vaccines:

Influenza vaccine (excluding H 1N 1): Hualan Bio, Changchun Changsheng, Beijing Kexing, Sanofi, GSK, Zhejiang Tianyuan, Novartis, etc.

Rabies vaccine: Liaoning Chengda, Dalian Hanxin, Khyron, etc.

Hib conjugate vaccine: Lanzhou Institute, Yunnan Watson, GSK, Novartis, Sanofi.

ACYW 135 vaccine: Phyllostachys pubescens, Hualan, Tianyuan, Zhejiang, Kang Hua, Chengdu.

A+C conjugate vaccine: Yunnan Watson, Xiaozhu and Luoyi.

Vaccine varieties being developed by domestic enterprises in the field of preventive vaccines:

Research institutions and business processes of varieties under study

Human papillomavirus Xiamen University &; Beijing Wan Tai Phase II

Hong Kong University of Human Papillomavirus &; Basic Clinical Biology in zhifei

Clinical study on biological basis of human papillomavirus Hualan

Hepatitis E Vaccine Xiamen University &; Beijing Wan Tai Phase II

Dental caries vaccine Wuhan Institute of Biological Products

Pre-clinical study of rotavirus vaccine in Wuhan Institute of Biological Products

Hib-A+C zhifei biological submission (SFDA)

Combined pneumonia vaccine watson biological, zhifei biological preclinical.

Beijing Institute of Hand, Foot and Mouth Disease Vaccine, Hualan Bio, zhifei Bio, etc.

Epidemic influenza vaccine Beijing Kexing Phase I