The purpose of treatment is to control the occurrence of new skin lesions and prevent recurrence. Mainly through supportive treatment and drug treatment, while preventing complications.
Symptomatic treatment
General treatment:
Strengthen supportive therapy and give a nutritious and digestible diet; Pay attention to maintaining water-electrolyte balance; Doctors will give albumin, plasma or whole blood to patients with systemic failure. In addition, nursing the ulcer surface of skin and mucosa to prevent secondary infection is an important link to reduce mortality and improve curative effect. You can wipe the mucosal erosion with physiological saline cotton balls every day, and use exposure therapy for people with large skin injuries, pay attention to room temperature and cleanliness, and keep it ventilated and dry; If the ward conditions are poor, you can also cover the rotten surface with oil gauze to avoid infection.
medicine
1, systemic medication
(1) Glucocorticoid is the first choice to treat this disease. Once diagnosed, it should be used as soon as possible, and the initial dose should be enough to control the disease as soon as possible. The initial dose (first dose) should be determined according to the scope and severity of skin lesions. The condition should be closely observed after administration, and whether the treatment is effective is based on whether there are new blisters. If patients receive regular treatment according to the doctor's advice, most patients can gradually reduce the dosage or even stop taking drugs to achieve rehabilitation.
(2) Immunosuppressants: For moderate and severe patients, in order to improve the curative effect and reduce the dosage of glucocorticoids, immunosuppressants can be used in combination at the initial stage of treatment or when the effect of glucocorticoids alone is not significant. Commonly used are azathioprine, mycophenolate mofetil or cyclophosphamide.
(3) Others: Tripterygium wilfordii polyglycoside, dapsone, nicotinamide, tetracycline, levamisole, chlorambucil and other drugs also have certain therapeutic effects.
2. Local drugs
The wound can be cleaned with 1:8000 potassium permanganate solution or 1: 1000 benzalkonium bromide to keep the wound clean. In case of skin lesion infection, effective antibiotics can be selected for external use according to the results of bacterial culture; Oral mucosal injury can be gargled with mouthwash, or applied locally with iodine glycerin or 2.5% chlortetracycline glycerin.
Other treatments
Intravenous injection of human immunoglobulin, immunoadsorption or plasma exchange, and in vitro photochemical therapy also have certain curative effects on this disease.
Treatment cycle
The treatment cycle of pemphigus is usually 3-6 weeks, but it may vary from person to person due to the severity of the disease, treatment plan, treatment opportunity, personal physique and other factors.