Properties: tablets, capsules, sprays.
Indications: Nifedipine is one of calcium antagonists, which has the strongest dilating effect on coronary artery and peripheral artery, and has a significant inhibitory effect on vasospasm. It is the first choice drug for variant angina pectoris, and is suitable for preventing and treating angina pectoris of coronary heart disease, especially angina pectoris caused by variant angina pectoris and coronary artery spasm. It is suitable for all types of hypertension, and also has a good curative effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term administration. In addition, it is also suitable for patients with angina pectoris accompanied by respiratory obstructive diseases, and its curative effect is better than that of beta blockers.
Drug interaction: Combined with other antihypertensive drugs can enhance the antihypertensive effect. When used with beta blockers, severe hypotension may occur. When combined with digoxin, the clearance rate of digoxin can be reduced. When taking quinidine at the same time, the concentration of quinidine decreased. Cimetidine or ranitidine can slightly increase the concentration of this drug.
Contraindications: patients with hypotension and allergy to dihydropyridine drugs. Cardiovascular shock, acute myocardial infarction (within 8 days).
Adverse reactions of metoclopramide: metoclopramide is one of the commonly used drugs to treat hypertension, angina pectoris and myocardial infarction. With the continuous expansion of its use, adverse reactions are also heard from time to time.
It is reported that the total incidence of adverse effects of propranolol in recent 65,438+00 years can reach 65,438+05% ~ 50%, and the incidence can reach 5% after stopping taking the drug, especially those who died of severe hypotension after taking only 65,438+00 mg orally. The year before last, it was reported abroad that 1 79-year-old women developed cardiogenic shock after taking the first dose of propranolol 1 hour, and died after1hour. From 65438 to 0995, the clinical trials of foreign scholars showed that the risk of death caused by taking short-acting nifedipine increased significantly with the increase of dose (showing a strong dose dependence). The death risk ratio of those who take 30 ~ 50mg daily is 65438 0.06, that of those who take 60mg daily is 65438 0.88, and that of those who take 80mg daily is 2.83. In another controlled study, compared with diuretics or beta blockers, people who take calcium blockers such as nifedipine have a higher risk of myocardial infarction, and the higher the dose, the greater the risk of myocardial infarction.
It has been reported in China that the common adverse reactions of propranolol are 12%, dizziness 3%, headache 6%, nausea 4%, facial flushing tachycardia 15%, headache, dizziness, gait instability 10% and fatigue 5% ~10. According to statistics, about 2% ~ 5% patients have myoclonia and tremor, and some patients have severe Parkinson's disease. Angina pectoris is aggravated 1 1%, and angina pectoris is aggravated 10% in patients who take medicine for 20 ~ 30 minutes. 157 patients with acute myocardial infarction continued to take nifedipine for 6 weeks, and some patients were found to have enlarged myocardial infarction. 10 patients with intractable angina pectoris have symptomatic hypotension, angina pectoris and reversible myocardial ischemia when the oral dose of nifedipine is ≥80mg. Xintongding can also cause coronary artery ischemia, aggravate heart failure and induce pulmonary edema. 1 patient developed anaphylactic shock, 3 patients developed transient hypertension, and 1 patient developed ventricular premature beats.
In addition, it can occasionally cause upper gastrointestinal bleeding and liver function damage, and induce or aggravate diabetes. After taking 1 day, nocturia in 9 patients increased significantly, and 19 elderly patients developed acute urinary retention.
When used in severe hypertension or hypertensive emergency, about 25% patients have increased heart rate and ankle edema.
Long-term use of nifedipine will lead to impotence, and some men will also have breast hypertrophy. A 62-year-old female patient with stage ⅲ hypertension developed gingival swelling, pain and chewing difficulty after taking nifedipine for 4 years, and disappeared after stopping taking the drug.
Five patients with Eisenmenger syndrome developed cyanosis in different degrees after taking nifedipine. Two cases of premature delivery occurred when taking orally Xintongding to treat asthma. Animal experiments have confirmed that small doses of Xintongding have teratogenic effects and are toxic to embryos, so pregnant women are contraindicated.
There is also withdrawal syndrome: withdrawal or reduction after long-term treatment will lead to recurrence, aggravation and frequency increase of angina pectoris, and hemodynamic disorder.
In recent years, there have been reports about tinnitus caused by Xintongding sustained-release tablets.
It is a helpless choice for people to lower blood pressure with western medicine, because some drugs have great side effects, patients suffer from other diseases, some organs have problems, and sometimes blood pressure is very high. Choosing antihypertensive drugs may be a way to lower blood pressure at the expense of other internal organs, or even a destructive treatment. Choosing drugs must be worthy of our attention.
Liuwei Flavone Tea is a national patent food tea for lowering blood pressure. They are all Chinese herbal medicines with the same origin of medicine and food, and have no side effects. It is recommended to try it, because there are many factors that cause hypertension, and each patient's individual differences are also great. Not all drugs will have an effect on every patient. If the antihypertensive effect is good after trial, drinking tea for a lifetime is better than taking medicine for a lifetime. If not, there is no loss in choosing western medicine, and it is also an opportunity to avoid the side effects of medication.