2. Rosuvastatin is the statins with the best lipid-lowering effect. A small dose can achieve a strong lipid-lowering effect, and its lipid-lowering ability of 5mg dose is equivalent to that of atorvastatin 20mg. According to the data, the blood lipid level of China people is generally lower than that of foreigners, so it is recommended to take low-intensity statins. Avastatin 80mg has no experience in China and should be used with caution.
3. Water-soluble statins are not easy to enter other tissues outside the liver, showing high liver selectivity and little influence on smooth muscle proliferation; However, fat-soluble statins are more likely to penetrate the blood-brain barrier, and are prone to central nervous system symptoms, such as insomnia. As can be seen from the following table, only rosuvastatin and pravastatin are water-soluble drugs with good liver selectivity and muscle safety.
4. There are racial differences in cholesterol levels. China people's cholesterol level is generally low, and they are more sensitive to lipid-lowering drugs. In addition, the serious adverse reactions caused by statins are positively correlated with the dose, that is, the greater the dose, the more adverse reactions. Lunan Pharmaceutical broke through foreign patent technical barriers and overcame many difficulties. After 10 years of research and development, the specification of rosuvastatin (Ruizhi) 5mg was pioneered, which was rated as a national key product and won the second prize of national scientific and technological progress. It was certified by the US FDA and was more suitable for China people. Powerful lipid-lowering, stable plaque, higher safety, and opening a new era of statin lipid-regulating.