Telomerase is an alkaline nucleoprotein reverse transcriptase, which can add telomere DNA to the chromosome end of eukaryotic cells. Telomeres play an important role in maintaining chromosome stability and cell activity in cells of different species. Telomerase can prolong shortened telomeres (shortened telomeres have limited cell replication ability), thus enhancing cell proliferation ability in vitro. Telomerase activity is inhibited in normal human tissues and reactivated in tumors, and telomerase may participate in malignant transformation. Telomerase plays an important role in maintaining telomere stability, genome integrity, long-term cell activity and potential ability of continuous proliferation.
? There is an enzyme in cells that is responsible for telomere elongation. Its name is telomerase. The existence of telomerase can make up for the defects of DNA cloning mechanism. By prolonging telomere repair, telomeres will not be lost due to cell division, thus increasing the number of cell division clones. ?
? However, in normal human cells, telomerase activity is strictly regulated. Active telomerase can only be detected in hematopoietic cells, stem cells and germ cells that must be continuously divided and cloned. When cells differentiate and mature, they must be responsible for the needs of different tissues in the body and perform their duties, so the activity of telomerase will gradually disappear. It is not important for cells to continue to divide and clone, but differentiated cells will undertake a more important mission, that is, to make tissues and organs run and make life last, but not forever. This cycle of alternating generations is the creator's ingenious thinking on life design.
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