Shunerning is a leukotriene receptor antagonist with strong selectivity, which is suitable for the treatment of asthma in adults and children, and can also be used to treat allergic rhinitis and allergic rhinitis asthma syndrome. Its chemical name is Montelukast. At present, it is widely used in China to treat cough and asthmatic asthma caused by respiratory allergy in children. There are reports of adverse reactions such as allergic drug sensitization. The clinical efficacy and side effects of Shunerning are described below:
(1) efficacy evaluation
The dose of Shuerning 10 mg is more effective than placebo. The results of another similar experiment showed that the PEFR of patients with chronic asthma increased after the application of 10 mg of Shunerning, and the number of acute attacks of asthma decreased significantly after the application of 10mg and 50mg of Shunerning. In addition, the daytime symptom score, the inhalation of β2 receptor agonists (such as salbutamol) and the quality of asthma-related sexual life in the control group were significantly relieved.
The comparative study of the three dosage groups of Shunerning (2mg, 10mg and 50mg) found that the symptom control of patients with chronic asthma in the dosage groups of 10mg and 50mg was obviously better than that in the dosage group of 2mg, suggesting that its curative effect was dose-dependent.
Long-term treatment (March) with a single dose of Sunanin( 10mg// day) also proved to be effective in treating asthma attacks. Compared with beclomethasone dipropionate (400μg/ day) in March, FEV 1.0 increased by 65438 after Shu Ning treatment.
Shunerning is also effective in treating allergic cough's disease, cough variant asthma and bronchial asthma in children aged 6 months to 14 years, but there is no significant difference between the two groups in the symptoms of cough and asthma during the day, PEFR in the morning and evening, waking up at night and the days of suspension from school.
(2) Side effects
On March 27th, 2008, the US Food and Drug Administration (FDA) issued an announcement [Announcement 03/27/2008] to medical staff and patients, arguing that the use of Shunerning may cause behavioral/emotional changes and suicidal tendencies and behaviors. At present, parents have reported that their children have become irritable after taking Shunerning for three months. Parents of allergic children who take Shunerning should closely observe and report to the doctor in time once they find that their children's behavior/mood has changed. For children who take medicine, we should pay attention to whether the child will be active, inattentive, aggressive, sleepy and depressed.
In 2009, after investigation, FDA officially stated that three asthma drugs, such as Shunerning, may cause mental problems, and relevant manufacturers need to highlight the drug risks on the drug labels. The FDA issued a statement on its website, pointing out that some consumers who took "Shuerning", "Ackroyd" and "Zileton" had depression, anxiety and suicidal tendency. The FDA investigation confirmed that these three asthma drugs may cause mental problems. The FDA said that both doctors and patients need to be aware of the potential risks of these drugs to mental health.
(3) What about asthma in allergic cough?
1, actively looking for allergens. It is common to inhale some plant pollen, indoor dust, mites, fungal spores, animal dander, fish and shrimp in food or in contact with paint dyes. Before each cough attack, carefully observe what factors exist, find out the allergic factors, avoid them and prevent contact again.
2. Avoid incentives. There are three possible reasons for cough variant asthma attack: first, climate change, high incidence in winter and spring, and cold air stimulation as the main reason, so it is necessary to do warm protection, especially to wear warm clothes and masks when going out in the early morning of winter; Second, the cough is aggravated after exercise, and children with such asthma should avoid strenuous exercise; Third, emotional excitement and crying can also induce cough attacks, so try to make your child emotionally stable.
3. Enhance the immune function of the body. The essence of cough variant asthma is asthma, and asthma is an allergic disease, that is, allergic reaction caused by abnormal immune function, so we should pay attention to improving and enhancing the immune function of the body. At present, Kangminyuan enhanced version, a special anti-allergic probiotic preparation, has been widely used to adjust allergic constitution and enhance anti-allergic ability. Using this simple and safe anti-allergic immune enhancer has greatly improved the prevention and treatment effect of asthma in allergic cough.
4. The principle of treating cough variant asthma is the same as asthma, because the pathogenesis is the same as asthma, and there are pathological changes of chronic allergic inflammation and airway hyperresponsiveness. Therefore, long-term use of controlled drugs-inhaled sex hormones or leukotriene receptor antagonists can achieve better curative effect, and the course of treatment can be shorter than that of asthma. Although the anti-inflammatory effect of leukotriene receptor antagonist is not as strong as that of hormone, it can be recommended for children who are unwilling to use inhaled hormone or whose condition is mild. At present, drugs such as Shunerning are commonly used to control the symptoms of respiratory asthma in allergic cough for a long time, and they are also used together with inhaled glucocorticoids (such as pulmicort and fluoxetine). However, because these treatments only treat the symptoms, they are not suitable for long-term inhalation, and they really rely too much on the control of anti-allergic drugs to stop taking drugs. As long as the drug is stopped, it will recur or aggravate the cough and cause asthma. Failure to cooperate with immunotherapy or radical measures is also an important reason why many children with asthma rely on inhaled sex hormones for a long time and cannot stop taking drugs or drugs.
5. The antiallergic effect of compound antiallergic probiotics Kangminyuan probiotics on children's allergic cough;
Studies have confirmed that Lactobacillus salivarius LS, Lactobacillus Grignard, Lactobacillus yoelii, Lactobacillus lactobacillus paracasei and Lactobacillus Roy all have significant antiallergic functions, among which Lactobacillus salivarius is the most researched isolated strain of antiallergic lactic acid bacteria. Lactobacillus salivarius, Lactobacillus Grignard, Lactobacillus yoelii and lactobacillus paracasei constitute a compound antiallergic probiotic, which significantly reduces the individual differences of antiallergic functions and has more comprehensive antiallergic ability than a single antiallergic strain.
1, Lactobacillus salivarius has a significant effect on dermoid allergic reaction, and the published paper shows that Lactobacillus salivarius has a better effect on severe atopic dermatitis in children: double-blind, random, effective and safe. The publication is: Pediatric Dermatology 20 1 1, and this strain has obtained the patent of antiallergic invention in China with the patent number of ZL 2007 1068.
2. Lactobacillus Grignard has a significant effect on mucosal allergic reaction, and Lactobacillus Epidermis has a significant effect on children with asthma complicated with allergic rhinitis. Announced: Pediatric Pulmonary Science 20 10, the strain obtained the patent of China antiallergic invention, ZL patent number 2010/053533.6;
3. Lactobacillus yoelii has significant effects on both types of allergic reactions, and published papers think that Lactobacillus yoelii can regulate pro-inflammatory cytokines, and then regulate allergic reactions. Publication: FEMS Journal of Microbiology 2007; ;
4. Lactobacillus lactobacillus paracasei and Roy
In order to improve the comprehensiveness of immune regulation of allergic patients and solve the difference between diseases and constitutions, Kangminyuan Probiotics, a compound antiallergic strain, uses functional strains screened from nearly 200 blood samples. After taking it, the self-improvement effect reaches more than 90%, which is more remarkable than that of a single strain.
product function
1. can effectively change various allergies, including allergic rhinitis, conjunctivitis, atopic dermatitis, urticaria, food, pollen and other allergic symptoms.
2. Adjust the allergic constitution to prevent the baby from being allergic.
3. Prevent colds and reduce bacterial and viral infections (enterovirus, rhinovirus, respiratory fusion virus).
4. Long-term supplementation can stabilize the intestinal flora, maintain the intestinal ecology of more bacteria and less bad bacteria, and then stimulate the mucosal immune system.
5. Strengthen the stomach, promote nutrient absorption and improve hematopoietic function.
6. Treat acute diarrhea, flatulence and intestinal dryness.
7. excrete intestinal endotoxin and delay aging.
The International Immunotherapy or Radical Measures for Allergic Asthma in Children claims that when allergic diseases occur, such as allergic eczema, urticaria, children's recurrent allergic rhinitis, recurrent allergic cough and asthma, the number of TH 1 cells will decrease due to the immune response in the human body. Under the stimulation of allergens, various cytokines such as IgE and eosinophilia are continuously produced, which promotes the immune response to TH2 pathway and forms humoral immune response. Supplementing Kangminyuan probiotics, a compound antiallergic probiotic composition for children with cough and asthma, can participate in the regulation of immune cytokines. This rare probiotic with antiallergic activity can promote the secretion of interferon in vivo to regulate TH 1 immune response and resist immunoglobulin IgE. By enhancing the TH 1 immune response of immune cells to regulate TH2 immune response which is overreacted due to allergy, children's anti-allergic ability can be improved. This safe Kangminyuan probiotic anti-allergic immune intervention regulation therapy can greatly reduce or shorten the course of anti-allergic western medicine, regulate immunity and reduce allergies.