PHA: polyhydroxyalkanoate, translated from English into polyhydroxyalkanoate, is an intracellular polyester synthesized by many bacteria. It mainly exists as a carbon source and energy storage substance in organisms. It has many excellent properties, such as physical and chemical properties similar to those of synthetic plastics and biodegradability that synthetic plastics do not have. It is a material, sometimes written as PHAs.
PHB: Poly-β-hydroxybutyric acid (translated from English as Poly-β-hydroxybutyric acid) is a carbon source storage, which exists in the cytoplasm of many bacteria and belongs to lipids. Insoluble in water, soluble in chloroform, and can be dyed with Nile blue or Sudan black. It has the functions of storing energy and carbon source and reducing intracellular osmotic pressure.
PHBV: English translation is polyhydroxybutyrate -co- valerate, which is a new biopolymer of 3- hydroxybutyrate and 3- hydroxyvalerate. It is a kind of biomaterial with starch as raw material and produced by fermentation engineering technology. It has complete biocompatibility and high barrier to water and gas.
PHA application
PHA plays a more and more important role in drug delivery system because of its good biodegradability and biocompatibility. The earliest study of PHA as drug-coated microspheres was the study of PHB in 1983. With the development of PHBV, the research of drug-coated PHA has made great progress.
The study shows that the monomer composition of PHA can be adjusted. Molecular weight? How many drugs are packed? The size of coated particles realizes the controlled release of drugs. In addition, many scholars also use other polymers such as PCL and PHA to mix and encapsulate drugs, and have also achieved certain results.
In the upsurge of PHA research in recent ten years, although the main technical patents in production and application are still in the United States? Oh? Japan and other developed countries and regions, but China has made great progress in this field in recent years, and has mastered some strains and post-processing technologies with independent intellectual property rights in production.
Especially in the last two years, there have been good research results in tissue engineering research, and many patents are in the public period, which has laid a good foundation for PHA to be a biomaterial with independent intellectual property rights in China in the future.
The above contents refer to Baidu Encyclopedia-polyhydroxy fatty acid esters.