Shandong biomedical research institute
Contact: Mr. Zhu 0531-812130860531-813080.
Other projects to be handed over by our hospital are:
1. Donipenem raw materials and powder injection: chemical 3. 1, broad-spectrum antibiotics, anti-bacterial infection, broad antibacterial spectrum, stable to most β -lactamases and transferred to clinical approval.
2. Clofarabine, injection and lyophilized powder for injection: 3. 1, used to treat acute lymphoblastic leukemia and acute myeloid leukemia. It is the only chemotherapy drug that can be specially used for childhood leukemia at present, and the clinical approval is transferred.
3. Irinotecan powder injection and raw materials: 6 kinds of chemical drugs, recommended for the treatment of patients with advanced colorectal cancer, can be used alone or in combination; It is also effective for patients who are ineffective in other commonly used drugs in clinic and need to declare production and transfer to new drug technology.
4. Tigecycline freeze-dried powder injection and raw materials: 3. 1, a broad-spectrum antibiotic, used to treat adult abdominal infection and complex skin and soft tissue infection. It has the advantages of drug-resistant bacteria, wide antibacterial spectrum and small side effects, and is transferred to clinical examination and approval.
5. Metoprolol ophthalmic instant gel: five kinds of chemicals, which are exclusively developed by China, have been reported to SFDA and transferred to clinical examination and approval.
6. Nallinamin nasal gel: it is developed exclusively in China to treat various rhinitis, and has obtained clinical approval and clinical approval transfer.
7. Levofloxacin Hydrochloride Ear Drops: 2 kinds of traditional Chinese medicines, which are exclusively developed in China, have a significant effect on otitis media. Pre-clinical research has been completed and clinical documents have been transferred.
8. Flutramadol cream and raw materials: 3. 1 class chemicals, which are exclusively developed in China and used to treat superficial fungal infections. Clinical approval has been obtained and transferred.
9. Buconazol nitrate vaginal cream, effervescent tablets and raw materials: 3. 1 class chemicals, with remarkable curative effect and novel dosage form. Preclinical research has been completed and clinical approval has been transferred.
10. Compound sodium cromoglycate nasal spray: 3.2 kinds of chemicals, used to treat rhinitis. The clinical trial has been completed and the production approval has been transferred.
1 1. Guannamidine Tablets and raw materials: 3. 1 Class, non-steroidal anti-inflammatory drugs, used to treat rheumatoid arthritis, osteoarthritis, extra-articular rheumatism and postoperative pain, have been clinically approved and approved for transfer.
12. ophthalmic instant gel (in situ gel): the latest dosage form, exclusive patent and technical platform. The developed products include brimonidine tartrate instant gel, levofloxacin hydrochloride instant gel and metoprolol instant gel.
13. Compound gentamycin sulfate eye drops Sulfate and Eye Ointment: Four original research drugs, which are exclusively developed in China, are used to treat eye bacterial infections. The clinical trial has been completed and the production approval has been transferred.
14. Zatobrofen tablets, capsules, raw materials: 3. 1, used to treat chronic rheumatoid arthritis, deformed arthritis, low back pain, scapulohumeral periarthritis, neck-shoulder-wrist syndrome, postoperative anti-inflammatory and analgesic, trauma and tooth extraction. Its effect is stronger than that of indomethacin, diclofenac, ibuprofen, aminopyrine and other similar drugs. Transfer clinical files.
15. Xinluotong tablet: 6 kinds of Chinese medicines, patented products, used to treat angina pectoris of coronary heart disease with qi deficiency and blood stasis. After the clinical trial, turn to production approval.
16. Xiaoer Yanbian Capsule: 8 kinds of traditional Chinese medicines, which are used to treat sore throat and tongue erosion caused by hyperactivity of lung heat. Clinical approval has been obtained and transferred.
17. Xiaoer Yanbian Oral Liquid: 8 kinds of traditional Chinese medicines, which are used to treat sore throat and tongue erosion caused by lung excess heat. Clinical approval has been obtained and transferred.
18. naomaixin granule: 6 kinds of Chinese medicines and patented products for treating cerebral ischemia, cerebral embolism and cerebral thrombosis. After the clinical trial, the production approval is transferred.
19. Qianlie Shuqing Granules: Six kinds of traditional Chinese medicines, patented products for treating chronic prostatitis and prostatic hyperplasia, have obtained clinical approval, and the clinical approval has been transferred.
20. Meng Xin Granule: 6 kinds of traditional Chinese medicines, patented products for the treatment of insomnia, have obtained clinical approval, and the clinical approval has been transferred.
2 1. Oral patch of total flavonoids from lateral calyx: 5 kinds of traditional Chinese medicines, patented products, which have been reported to SFDA and transferred to clinical examination and approval.
22. Frankincense Tongbi Tablets: five kinds of Chinese medicines, patented products for the treatment of rheumatoid arthritis, have obtained clinical approvals and clinical approvals have been transferred.
23. Xanthan gum: Xanthan gum is the largest and most widely used microbial polysaccharide in the world, which can be used in food industry, petroleum industry, material industry, textile industry, coating industry and other industries. The production process of xanthan gum developed by our hospital has reached 29g/L in 48h, and its technical index has reached that of similar products in China. Now the production technology has shifted.
Gellan gum: Gellan gum is one of the most promising microbial polysaccharides in recent years. As emulsifier, suspending agent, thickener, stabilizer, gelling agent, tissue culture medium, film-forming agent and lubricant, it is widely used in many industries such as food, beverage, cosmetics, detergents, ceramics, petroleum exploitation and chemical coatings. Its characteristics: 1, less dosage; 2. Thermal stability and acid resistance; 3. Excellent taste; 4, extremely high gel transparency; 5. Adjustable elasticity and hardness; 6. Good compatibility. The production process of gellan gum developed by our institute, the fermentation level is coarse gum 10- 12g/L and clear gum 5-6g/L in 48-72h, and the technical index reaches the index of domestic similar products. Now the production technology has shifted.
25. Natamycin: Natamycin is an important polyene antibiotic, which can effectively inhibit the growth of yeast and mold, prevent the formation of aflatoxin in filamentous fungi, and treat diseases caused by fungi. Due to the low solubility of natamycin, the shelf life of food can be prolonged by treating the surface of food, and the flavor and taste of food will not be affected. At present, natamycin, as a natural food preservative, has been approved for use in many food industries such as dairy products, meat, fruits and beverages. Natamycin fermentation technology developed by our hospital is at the leading level in China. The 5-day fermentation level is 6g/L, which can be industrialized. Now the production technology has shifted.
26. Pullulan: water-soluble mucopolysaccharide, widely used in food industry, pharmaceutical industry, petroleum and building materials industry. Our output and substrate conversion rate are comparable to those of Japan Linyuan Company, and the fermentation level is 60g/L within 48 hours. It has advanced purification technology and has realized industrial production. Transfer the production process.
27. Low molecular weight pullulan: The production technology of pullulan is further developed and researched, which is specially used to produce pullulan with molecular weight below 50,000, which is suitable for special purposes. Now transfer the production process.
28. Chitooligosaccharides: Chitooligosaccharides are oligosaccharides with a degree of polymerization of 2- 20, which are linked by 2-glucosamine through β- 1, 4- glycosidic bonds, among which chitooligosaccharides with a degree of polymerization of 6-8 have good antibacterial, immune enhancement and anti-tumor activities. The production process developed by our hospital can prepare white powdered chitosan oligosaccharide with sugar content, polymerization degree of 6-8, good water solubility, color and internal quality reaching or exceeding Korean products. Now the production process has shifted.
29. Xylo-oligosaccharide: Xylo-oligosaccharide is a functional oligosaccharide composed of 2-8 xylose linked by β- 1, 4- glycoside bond. It is a Bifidobacterium factor with superior performance, unique acid stability, difficult to ferment, difficult to be decomposed by human digestive enzymes, and has a highly selective proliferation effect on Bifidobacterium in vivo. Can be widely used as food additives in medicines, health foods, beverages, sweets, cakes, ice cream, milk powder, dairy products, condiments and feeds. At present, high-temperature enzymes have been used in industrial production of 70 syrup, 70 powdered sugar, 95 powdered sugar, 95 syrup and other different series. The product quality can reach the highest level in China, and the production process is transferred.
30. Epidermal growth factor: Human epidermal growth factor is a polypeptide that promotes epidermal growth and can be used for corneal transplantation, burn and trauma treatment. Human epidermal growth factor is generally produced by genetically engineered bacteria. A genetically engineered Escherichia coli strain has been obtained in our hospital, which can be used to produce human epidermal growth factor. The product is highly expressed and secreted out of the cell, which is easy to separate and purify. After testing, the product has natural conformation, high biological activity, little side effect, specific activity unit ≥5× 105IU/mg, and purity ≥95%. Now transfer the production process.