Overview of TAP: Abnormal glycoprotein (TAP) is mainly caused by incomplete glycosylation or new glycosyltransferase is activated to produce new glycosylation. A large number of studies have shown that abnormal glycoproteins are closely related to tumors.
For example, the sugar chain structure of alpha fetoprotein, transferrin, alkaline phosphatase, r- glutamyltransferase, human chorionic gonadotropin, T antigen, a 1 antitrypsin and prostate acid phosphatase in patients with malignant tumor has changed, and these substances are discharged into the blood to some extent and more exist in peripheral blood. Studies have shown that it is a new technology developed in recent years to diagnose tumors by using the abnormal sugar chain structure of glycoprotein excreted during tumor cell metabolism.
Abnormal glycoprotein (TAP) is closely related to tumor. There are hundreds of papers at home and abroad on the mechanism, principle and basic research of using abnormal glycoprotein to detect tumors, and the highest impact factor is 34.48. TAP detection reagent contains more than a dozen lectins. Through the patented technology-multistage coupling reaction, more than 20 abnormal glycoproteins closely related to tumors can be detected at one time in the same reaction system.
TAP detection reagent obtained the third class medical device product registration certificate issued by the US Food and Drug Administration in February, 201/. TAP detection technology was introduced by Premier Li Peng from the Ukrainian Academy of Medical Sciences in the former Soviet Union on 1995, and passed the expert acceptance organized by the Ministry of Science and Technology.
It is an industrial application of the National 973 Project, an international advanced scientific and technological achievement led by the Ministry of Science and Technology, a "national double-cited project" and a "key project of international scientific and technological cooperation" accepted by the Ministry of Science and Technology, and listed as a "national torch plan project". After more than ten years' demonstration by experts at home and abroad, it was listed in the list of clinical inspection items of national medical institutions by the Ministry of Health, the highest academic authority, in 20 13.