Ekdoine, a rookie in repairing barriers, have you heard of it?
No?
Then Hachi, let me introduce you to this rookie who is repairing anti-aging!
You may not know this place, but you have seen similar photos at some time-
The pink "mirror of the sky" is real. The picture above shows Lake Sivash in Crimea.
Just looking at the photos, this is a charming pink wonderland.
But actually approaching this lake, you will find that it is not so beautiful-the lake area is barren and filled with rancid breath.
This is because the salinity in the lake area is so high that most organisms cannot survive. Here, all halophilic microorganisms (halophilic bacteria) that adapted to the high-salt environment in the process of evolution finally survived. The pink of the lake is the color of halophilic bacteria. Because the lake is shallow and has more silt, it is very suitable for halophilic bacteria to breed, so it gives off a strong rancid smell.
Not only Sivash Lake, but also many high salt lakes and saline-alkali land, such as Chaka Salt Lake and Chaerhan Salt Lake in Qinghai, China.
All creatures living in desperation are "superior in skills and daring" and possess top secret weapons, and the above halophilic bacteria are no exception.
There is a natural protective component outside their cells, which can adjust osmotic pressure and make them adapt to survive in high temperature, dryness, strong ultraviolet radiation and high salinity environment.
This ingredient is tetrahydrofolic acid.
Ekdoine's chemical name "tetrahydromethylpyrimidine carboxylic acid" is a natural cytoprotective agent and an amino acid derivative produced by bacteria.
It can not only balance the osmotic pressure of cells, but also play a good role in protecting enzymes, DNA, protein, nucleic acid, cell membrane and the whole cell under severe conditions such as high temperature, severe cold, drought, extreme pH value, high pressure, high salt and high radiation.
In fact, Hector has been used in the field of microbiology for a long time, both for oral use and external use. In the application of Actolin in the field of beauty, there is a famous document about the light protection function of UVA:
In this paper, the protective effect of Hector forest on cultured human epidermal keratinocytes was introduced in detail.
On the left, cell markers (intercellular adhesion factor, ICAM- 1, a pro-inflammatory factor) increase after exposure to UVA for a period of time. On the right, cells added with lidocaine were also exposed to UVA for some time. In contrast, under the protection of ecdysterone, proinflammatory factors decreased significantly.
The researchers speculate that it is precisely because of Hector Lin's intervention in mitochondrial-mediated cell damage (signal pathway initiated by ceramide in cell membrane, inducing mitochondria to release cytochrome C and activating the expression of inflammatory factors in keratinocytes through AP-2) that it plays a protective role:
Icedoine has been widely used in enzyme preparation, biomedicine and skin care products. For example, for some functional products with high acid content or antioxidant content, in order to increase skin tolerance, Hector Lin will be added to help the skin reduce sensitivity and irritation while gaining benefits. A large number of sunscreen products will use Hector Lin to increase the skin's ability to resist ultraviolet rays.
Generally speaking, the role of Hector forest is as follows:
① isolate the stimulus source
The cyclic structure of ekdoine molecule has strong electronegativity, and it is easy to form hydrogen bonds with water molecules, which enhances the association ability of water molecules, makes water molecules directionally arrange around it, and changes the spatial arrangement of water molecules. In other words, it can form an isolation layer around cells, enzymes, protein and other biomolecules. Because of the existence of the isolation layer, skin cells are "fully armed" and have better "anti-beating ability", which blocks or reduces the stimulation of external stimuli to skin cells, thus alleviating the symptoms of adverse reactions.
② Enhance skin immunity.
Icedoine can effectively protect Langerhans cells (Langerhans cells are important immune cells in the skin, located between keratinocytes in the skin epidermis, protecting the skin from microorganisms, ultraviolet rays, allergens and so on. ) from external stimuli, thereby enhancing skin immunity and making people have a strong skin physique.
③ Accelerate cell repair.
When skin cells are subjected to environmental pressure, such as high temperature, ultraviolet rays, hypoxia, heavy metal poisoning, virus infection, etc. Hector forest will produce emergency protection and regeneration reaction, produce heat shock protein, and help each cell maintain normal physiological activities.
④ Prevent ultraviolet damage.
Ultraviolet rays can cause photoaging and accelerate skin aging. However, Hector forest can prevent the chain reaction caused by UVA irradiation and prevent the mutation of mt-DNA caused by UVA.
⑤ Improve the skin's ability to lock water.
Under normal circumstances, adults lose about 240-480 ml of water through the skin surface every day. When the cuticle of the skin is seriously damaged, the water loss can be increased by 10 times. Ecdystrophy can penetrate deep into the epidermis and repair the skin water locking system.
⑥ Anti-aging and wrinkle removal.
People's eyes get old before they get old, and they can't erase the traces of time.
To evaluate an anti-aging product, the first thing to see is whether it can improve crow's feet. In this regard, from the data point of view, Ekdoine's performance can be said to be very brilliant.
Let's take a look at the feedback map of real people. It can be seen that Hector Lin can effectively improve the skin surface condition, and has obvious wrinkle removal effect by naked eye observation.
Compared with the anti-aging ingredients such as Aidiben+complex acid and alcohol A+ ester A, it is milder but has good effect, and is praised as "magic repair factor" by the industry.
Limited by the patent right, few domestic cosmetics were added with Hector forest in the past. However, with the expiration of Hector Lin patent applied by German Merck Company in 2065 438+09-2022, domestic enterprises launched fierce competition for products focusing on this ingredient, and mainly adopted a process called "bacterial milking" for commercial production, and its application scope has been extended to sunscreen, cleansing, makeup, eye care, hair care and so on.