What diseases are gonococcus, mycoplasma and chlamydia?

Mycoplasma: Mycoplasma is the smallest known living organism and the smallest prokaryotic cell. It is a prokaryotic microorganism larger than virus and smaller than bacteria. Their outstanding feature is that they have no cell wall. So cells are soft, changeable in shape and highly polymorphic. Observation of mycoplasma cells under electron microscope showed that there were cell membrane, ribosome, RNA and circular DNA in the cells. Mycoplasma widely exists in soil, sewage, insects, vertebrates and human beings, and is one of the pathogenic bacteria of animals, plants and humans. Chlamydia: Chlamydia is a widely spread pathogen in nature. Most of them are spherical, with piles and cell walls, so they are generally parasitic in animal cells. In the past, they were classified as viruses, but later they were found to belong to their own category. It is a prokaryotic microorganism larger than a virus and smaller than a bacterium. It is spherical with a diameter of only 0.3-0.5 micron. It has no athletic ability. Chlamydia is widely parasitic in humans, mammals and birds, and only a few of them are pathogenic. Chlamydia is a gram-negative pathogen and an obligate intracellular microorganism. It has no ability to synthesize high-energy compounds ATP and GTP, and must be provided by the host cell, thus becoming an energy parasite. Chlamydia is a prokaryotic cell microorganism, which can pass through the cell filter, has a unique development cycle and is strictly intracellular parasitic. It is mainly transmitted through sexual contact. After entering the reproductive tract, they like to grow and reproduce in mucosal cells, causing female endometritis, salpingitis, pelvic inflammatory disease, urethritis and so on. It can cause inflammation such as male urethritis, epididymitis and proctitis. Women infected with chlamydia trachomatis can cause infertility, ectopic pregnancy (ectopic pregnancy), abortion, stillbirth, premature rupture of membranes, premature delivery and so on. 【 Pathogenesis 】 After mycoplasma and chlamydia infect human body, they first invade columnar epithelial cells, grow and reproduce in the cells, and then enter the cells of mononuclear phagocyte system to proliferate. Because mycoplasma and chlamydia multiply in cells, infected cells die, and at the same time, they can escape the immune defense function of the host and get intermittent protection. The pathogenic mechanism of mycoplasma and chlamydia is to inhibit the metabolism of infected cells, dissolve and destroy cells, lead to the release of lysozyme, the cytotoxic effect of metabolites, and cause allergic reactions and autoimmunity. Neisseria gonorrhoeae is a kind of bacteria. Microscopically, Neisseria gonorrhoeae is oval or coffee bean-shaped, arranged in pairs with pili; It is afraid of high temperature drying, and can survive in dry environment for less than 2 hours, but it can survive in underwear, bedding and toilet cover for 18~24 hours. It can cause purulent infection of urogenital system. Fluorescent quantitative PCR(FQ -PCR) was used to detect Neisseria gonorrhoeae quickly and accurately, and the positive detection rate, sensitivity and specificity of this method were discussed.