The so-called stem cell beauty, one is to inject stem cells into the relevant parts of the body, and the other is to apply some small molecules with active peptides to specific parts through the outside world to stimulate "awakening" or nourish epidermal or dermal stem cells. The source of stem cells for injection in the former is mainly extracted from aborted embryos. Some small molecular viruses, such as hepatitis virus, syphilis, HIV, etc., will inevitably be inactivated incompletely in extraction technology. If the embryonic stem cells are not matched directly, it will easily lead to immune rejection. In addition, when stem cells enter the body and mature, they will attack the recipient's skin, liver, kidney and so on. , causing damage to tissues and organs. Academician Zhai Zhonghe, a cell biologist and academician of China Academy of Sciences, said: "Early embryonic stem cells are prone to canceration, which may lead to malignant transformation of cells. Moreover, direct transplantation of stem cells still has potential risks of biological safety and virus infection, because many viruses such as AIDS are transmitted from mother to child and may be passed on to recipients. Therefore, direct injection of embryonic stem cells is extremely unscientific and extremely dangerous. " Therefore, the Ministry of Health and the US Food and Drug Administration have never issued or approved the application of this kind of products in the market, because this technology is still immature and there are many ethical problems. At present, the so-called stem cells for injection in the market are all operated in secret, and they are all operated in so-called private hospitals, clinics and beauty salons. Their safety is not guaranteed. In addition, the price charged is not approved by the price department, that is, it is illegal. These cases are also common in recent years.
Stem cells can be activated by external substances to increase their activity, and theoretical and experimental data have been confirmed. In stem cell beauty, we pay attention to epidermal stem cells, which are differentiated from embryonic stem cells, making the epidermis in a state of continuous proliferation, differentiation and shedding. They are the progenitor cells of various epidermal cells, which are derived from the ectoderm of embryos and have the ability of two-way differentiation. On the one hand, it can migrate downward and differentiate into epidermal basal layer, and then generate hair follicles; On the other hand, it can migrate upward and eventually differentiate into various epidermal cells. Epidermal stem cells are located in the basal layer of skin. At present, it is believed that epidermal stem cells produce progeny stem cells and temporarily expand cells during division. In healthy individuals, the maintenance of skin integrity depends on the self-renewal of epidermal stem cells and the terminal differentiation of their offspring cells. Epidermal stem cells remain at a normal level all their lives, and the process of skin aging is the result of the decrease in the number of cells that epidermal stem cells respond to proliferation signals. It may be that local environmental factors, rather than stem cells themselves, have an effect on skin aging, such as the role of exogenous signals. The functions of epidermal stem cells awakened by bioactive peptides are: 1. At the epidermal level, it affects the activity and growth factors of keratinocytes, stimulates the migration and epithelization of keratinocytes, stimulates the differentiation and correction of epidermal cells, and strongly promotes the repair and healing of epidermis. 2. Dermal layer: Stimulate the activity of fibroblasts, enhance the contraction and structure of extracellular matrix, provide skin nutrition, and promote skin wound healing and functional regeneration. 3. On the whole skin level: enhance the resistance to environmental invasion, ultraviolet rays, pollutants, irritants, allergens and inflammatory cells, consolidate and enhance skin tension, enhance skin elasticity, stimulate scar tissue regression, reduce scar formation and delay skin aging. The main mechanisms are: ① promoting the proliferation, division and differentiation of epidermal and dermal cells (especially fibroblasts, epithelial cells and endothelial cells), increasing the number of new cells, thickening the skin and gradually restoring the normal structure and physiological function of the skin; ② Promote the formation of collagen fiber, reticular fiber and elastic fiber, regulate the secretion of collagen and mucopolysaccharide, maintain the moisture content and electrolyte metabolism of skin tissue, improve the water shortage of atrophic skin and moisturize skin tissue; ③ Promote the formation of new capillaries in skin tissue through the action on vascular endothelial cells.
Adding bioactive peptides to the culture medium of human epithelial cells, fibroblasts, vascular endothelial cells and corneal cells cultured in vitro can significantly accelerate the division and proliferation of these cells. Through different kinds and grades of animal models such as mice, rats, rabbits and miniature pigs, it is observed that active peptides such as FGF can significantly induce angiogenesis, promote wound healing, accelerate wound healing and reduce scar formation, which is manifested by increased granulation tissue formation and thickening, increased collagen deposition, accelerated epithelial formation, accelerated maturation and number of fibroblasts, increased capillary bacterial models, improved local circulation and shortened healing time.
This active peptide raw material is also used in medicine and can be proved to be safe. Dr. Lu Jiahai of Sun Yat-sen University and his team, after years of research, extracted three kinds of active peptides with molecular weight of10 million from deep-sea fish eggs (patented). The experimental study on the mechanism of its action on human epidermal stem cells and animal models shows that it has many important biological effects and physiological functions. After more than seven years of practice and thousands of applications, it is found that this active peptide can obviously improve unhealthy skin conditions, such as skin wrinkles, relaxation and pigmentation. This further shows that bioactive peptides are related to the growth, division, differentiation, proliferation and migration of skin cells, which can provide skin nutrition, delay skin aging and promote skin wound repair. Both experimental research and clinical application show that adding bioactive peptides into beauty cosmetics can effectively interact with skin cells and exert its outstanding beauty and skin care efficacy, which is of great significance to improve the function of skin care products.