1999.12-2006.12 researcher and senior researcher, Bristol-Myers Squibb Institute of Medicine, USA.
1998.1-1999.11American Microgenomics Company is a researcher.
1997.1-1998.10 Professor Edward A. Dennis, University of California, San Diego, USA, is a postdoctoral fellow at NIH.
1996.7-1996.12 postdoctoral fellow, David T. Gibson Laboratory, Biocatalysis Center, University of Iowa, USA.
1991.1-1992.7 Texas a&m university (USA); Professor George Qiu Zhenyu is a visiting scholar in this laboratory.
1982.8-1990.12 assistant engineer and engineer of Suzhou Fisheries Research Institute, Jiangsu Province.
academic degree
1992.8 ——1996.7 Ph.D. in medicine and natural product chemistry, School of Pharmacy, University of Iowa, USA (tutor: Professor John P. N. Rosazza).
1978.10—1982.7 Bachelor degree in pharmacy, China Pharmaceutical University.
Projects are currently under way.
1. Head of the subject innovation and intelligence introduction program of the Ministry of Education and the State Administration of Foreign Experts Affairs ("11"program): Innovation and intelligence introduction base for drug biosynthesis and biotransformation (20/200812, 16544)
2. Person in charge of the key scientific and technological research project of the Ministry of Education: molecular structure modification of a new dicarbonyl reductase as an efficient biocatalyst (2008-2009,No. 108070).
Academic paper
34. Ji, Zheng, Mei, Feng Fucheng, Luo, Li Baolin and Chen Yuzhen. The synthetic lethal pancreatic cancer inhibitors were screened by chemical genes using the human pancreatic cancer cell model based on. Front. Biosci。 2008 is being printed.
33. Wu, Liu Xingrui, Liu, N.& bacterial enzyme that catalyzes the double reduction of β, δ-diketone ester with unprecedented stereoselectivity. Journal of Nature, 2008, HDL:10101/npre.
32.Hanson, R.L., Davis, B.L., Chen, Y.J., Goldberg, S.L., Parker, W.L., Tully, T.P., Montana, & Preparation of R- amine from racemic amine by S- amine transaminase from Bacillus megaterium. Synthetic. Qatar. 2008, 350(9), 1367- 1375.
3 1. Determination of enantiomeric excess of ethyl 3,5-dihydroxy -6- benzyloxy hexanoate by chiral reversed-phase high performance liquid chromatography. Chirality, 2008,20 (1), 5 1-53.
30. Chen Yijun * and Wu Xuri. Biocatalysis and new drug research and development, chemical progress, 2007, 19 (12), 1947- 1954. (special summary)
29. Liu Jianhong, Chen Yongguo, Yu Bingyan and Chen Jianhua; Streptomyces griseus 13273 transformed artemisinin ketone derivatives. Brug. Medicine. Chemistry. Ritter. 2006, 16 (2 1), 1909- 19 12.
28. Guo Zhiwei, Chen, Yang Jun, Gao Shiwani, A, Hansen, R.H. & Patel, R.N. Synthesis of (3R, 5S)- dihydroxy -6- benzyloxy ethyl hexanoate and tert-butyl ester by enantioselective and enantioselective microbial reduction. Tetrahedron: Asymmetric 2006, 17(8), 1589- 1602.
27. Chen Yongjie, Dourdy, Bachelor of Arts, Li, Huo Shide, Lin, Xing, Zhang and Li. Purification, functional cloning and characterization of phenylalanine aminomutase: the first step in taxol biosynthesis. Arch. Biochemistry. Biophysics. 2005, 438 ( 1), 1- 10.
26. Reguri-Ren, A, Carol, T.M., Chen, Y.J., mattson, J.A., Huang, S., Mazzucco, C.E., Sticker, T.M., Vias, D.M., & ampBalasubramanian, B.N. Core modified SOR. Brug. Medicine. Chemistry. Ritter. 2002, 12 (23), 3403-3405.
25. Serrano Wu, M, Saint Laurent. Chen, Yang Junjie, Huang, Lin, Huang Guosheng, Ma Songjie, Huang, Mazzucco, Stake, Dooley, Huang, Wei Yasi, Dai Mingde. Balasubramanian, B.N. Sordarin oxazeoine derivatives as effective antifungal agents. Brug. Medicine. Chemistry. Ritter. 2002, 12 ( 19), 2757-2760.
24.Canne, L.E., Botti, P., Simon, R.J., Chen, Y.J., Dennis, E.A .Kent, S.B.H, Chemical protein Synthesis by Solid-phase Connection of Unprotected Peptides, American Journal. Chemistry. Socialists1999,121(38), 8720-8727.
23. Yang, H.C., Mosior, M., Johnson, C., Chen, Y.J., & ampDennis, E.A. Group-specific analysis to distinguish four main types of phospholipase A2. Anal. Biochemistry. 1999, 269 (2), 278-288.
22. Chen Yijun & ampDennis, E.A. Expression and Characterization of Human Phospholipase A2. Biochemistry. Biophysics. Acta。 1998, 1349 ( 1), 57-64.
2 1. Chen Yijun, Luo Shasha, J.P., Rees, C.P., Chang, H.Y., Nowaksky, Master of Arts, & Microbial Model of Soil Metabolism: Microbial Transformation of Dafloxacin. J. Ind microbiota Biotechnology. 1997, 19 (5-6), 378-384.
20. Chen Yijun & amp oligopeptide as a substrate and inhibitor of a new constitutive nitric oxide synthase from rat cerebellum. Biochemistry. Biophysics. Joint resolutions 1996, 224 (2), 303-308.
19. Chen Yijun & Purification and characterization of nitric oxide synthase (NOSNoc) from Nocardia species. J. bacterial alcohol. 1995, 177 ( 17), 5 122-5 128.
18. Chen Yijun & ampRosazza, J.P. Microbial transformation of ibuprofen by Nocardia. Application environment. Microorganism. 1994, 60 (4), 1292- 1296.
17. Chen Yijun & amp bacterial nitric oxide synthase from Nocardia. Biochemistry. Biophysics. Joint resolutions1994,203 (2),1251-1258.
16. Jiuzhou, Guangzhou & Effect of anti-glaucoma drugs on ocular blood flow in rabbits with high intraocular pressure. J. eyepiece Pharmacology. 1993, 9, 13-24.
15. Jiuzhou, Guangzhou & Using dopamine antagonists to improve ocular blood flow in rabbits with high intraocular pressure. Acta。 China Pharmacopoeia, 1992, 13 (6), 48 1-484.
14. Jiuzhou, Guangzhou & Effects of dopamine agonist bromocriptine and some dopamine antagonists on ocular blood flow. J. eyepiece Pharmacology. 1992, 8 (4), 285-294.
13. Jiuzhou, Guangzhou & Effects of D- and L- isomers of timolol on retinal and choroidal blood flow in rabbits with ocular hypertension. Journal of Ophthalmology. 1992, 8 (3), 183- 190.
12. Qiu Guangchang, Shen Zhenfeng, Zheng Yongqiang, Zhang Yongqiang; Enhancement of systemic delivery of peptide drugs by ocular route with surfactants. Drug development. Resolutions 1992, 27 (2), 177- 183.
1 1. Chen Yijun, Jin Dongmei. Determination of total porphyrin in pearl powder by fluorescence spectrometry. China journal of fisheries. 1990, 14 (2), 157- 159.
10. Chen Yijun, Xia Ning, Wang Shuru, Chen Qionghua. Anti-aging effect of auricularia auricula, tremella fuciformis and tremella fuciformis spore polysaccharide. Modern applied pharmacy. 1989, 6 (2), 9- 10.
9. Tan, Bian Quanling and Nian. Study on anti-aging effect of Zhenzhu Kangleshou oral liquid. China Journal of Pharmacy.1989,24 (7), 407-409.
8. Chen Yijun, Hu Tianxi and Chen Xiuwu. Study on the anti-free radical effect of pearl porphyrin compounds by chemiluminescence analysis. Journal of Gerontology.1988,8 (2),109-10.
7. Tan, Nian, Gu Zhenlun, Zhuang Xingmei. Experimental study on anti-aging effect of pearl powder. Journal of Gerontology.1988,8 (2),109-10.
6. Years, Gu Zhenlun, Wang Enze, Hu Sichu, and Scarlett. Pharmacological study on the anti-aging effect of Jian Yan Ling. Chinese herbal medicine. 1988, 10 (7), 19-24.
5. Tan, Xu. Observation on the therapeutic effect of Zhenzhu Mingmu liquid on experimental cataract. Ophthalmology News.1987,6,9-11.
4. Chen Yijun. Study on the effect of Zhenzhu Mingmu liquid on experimental glaucoma. Ophthalmology News.1987,6,7-8.
3. Qian Ceng Nian, Gu Zhenlun, Chen Yijun, Wang Enze, Zhuang Xingmei, Zhu Lujia and Qian Xueshe. Pharmacological study on erxian chunhui capsule. Research on Chinese patent medicines, 1986, 1 1, 32-34.
2. In Qian Ceng, Chen Yijun, Gu Zhenlun and Zhuang Xingmei. Study on anti-aging activity and toxicity of Erxian Chunhui capsule. Journal of Suzhou Medical College1986,6 (1), 1 1- 16.
1. Li Naisan, Hao, Pharmacological study on racemic timolol, a hypotensive drug. Journal of Nanjing Pharmaceutical University. 1984, 15 (2), 40-44.
Non-academic articles
Chen Yijun & Liu, n. The Olympic Games may have a negative impact on China's research. Nature, 2008,454, 1049.
Patents applied for and granted
1.Patel, R.N., Chen, Y.J., Goldberg, S.L., Hanson, R.L., Gill, I., Goswami, A., Tully, T. and Parker, W. From R, S- amino acids or ketoacids. WO 2007/ 1 12299A2，US 2007/023 1858 a 1(2007)
2.Patel, R.N., Chu, L., Johnston, R.M., Guo, Z.W., Chen, Y.J., Goldberg, S.L., Hanson, R.L., Goswami, A. and Katipally, K. International applicationNo. 2006/ 130657A2 (2006), U.S. patent No.7,393,667, B2 (2008).
3.Rosazza, J.P. and Chen, Y.J. purified nitric oxide synthase. 6,988,446 USD 2 (2006)
4.Steele, C.L., Chen, Y.J., Dougherty, B.A., Hofstead, S., Lam, K., Li, W. and Xing, Z. Compositions and methods for altering the biosynthesis of taxanes and taxane-related compounds. WO 200306687 1A2 (2003), us 7,273,755b2 (2007)
5. Bacterial nitric oxide synthase. $5,759,835 (1998).
6.Rosazza, J.P. and Chen, Y.J. purified nitric oxide synthase from rat brain. Usa 5856 158( 1998).
7. Chen Yijun. 2- phenoxypyrimidine derivatives and their therapeutic uses. China Patent No.0 1 138070.5 (authorized)
8. Chen Yijun, Shi Lei. Dihydropyridone derivatives and their uses. China patent application number is 02 137829.0.
9. Chen Yijun oral spray for relieving or eliminating snoring and its preparation method. China Patent No.03113117.4 (authorized).
10. Chen Yijun is a dicarbonyl reductase and its gene and application. China patent application number is 200710135391.8.
Academic conferences and exchanges
In August, 2008, the invitation report of the 2nd Asia-Pacific Chemical Industry Alliance Biotechnology Conference (Dalian) was adopted by the conference.
Best academic report award
2008.7 Special Report of the Second National Interdisciplinary Seminar on protein Studies (Yantai)
2007. 1 1 Special Report of the Third International Conference on Bioenergy and Bioprocess Engineering (Shanghai)
2007. 1 1 Jinan University School of Life Sciences "Series of Academic Lectures for Famous Scholars" (Guangzhou)
2007. 10 Report of the 6th China Enzyme Engineering Seminar (Kunming) Invited Meeting.
August 2007: Invited Report of the 5th National Symposium on Chemical Biology (Kunming)
Keynote speech at the first Berkeley-China Center for Health Promotion International Summit (Shanghai) in May 2007.
2006. 1 1 Invited Report of the 5th World Symposium on Chemistry of Traditional Chinese Medicine (Nanjing)
1999.05 2 1 Special Report of Fuel and Chemical Biotechnology Forum (Colorado, USA)
1995.05 Report of the National Annual Meeting of American Society for Microbiology (Washington, USA)
Awards and honors
1. 1987 Suzhou Science and Technology Progress Award, Jiangsu Province
2. 1994- 1996 Excellent Doctoral Scholarship of Biocatalysis Center, University of Iowa, USA
3. 1996 was selected as the first batch of "Hundred Talents Program" distinguished professor of China Academy of Sciences.
4. 1997- 1998 National Institutes of Health (NIH/NCI) postdoctoral scholarship.