NEAA has good bioavailability, produces less metabolic waste, and has low biological valence, and produces more metabolic waste. According to the origin of protein, the content of animal protein EAA is high, and the content of plant protein NEAA is high.
When chronic renal failure (CRF) occurs, the function of excreting metabolic wastes by the kidneys is reduced or lost, and toxins mainly produced by protein are accumulated in the body. If you eat plant protein with high NEAA content again, your condition will be aggravated. In the past, it was thought that legumes were plant proteins with high content of NEAA, so CRF patients should fast. In recent years, new progress has been made in the research on the source of diet protein. Some scholars have found that the effect of diet based on plant protein on increasing glomerular filtration rate (GFR) of healthy people is lower than that of animal protein, indicating that the effect of plant protein on increasing GFR is lower than that of animal protein. This may be related to the contents of glycine, alanine, arginine and proline in animal protein, because these amino acids can increase GFR and glomerular blood flow. The increase of GFR and glomerular blood flow (also called high filtration) is an important mechanism to promote glomerular sclerosis and accelerate renal function damage. This result suggests that although the EAA content of plant protein is lower than that of animal protein, it has a weak high filtration effect, so it has a protective effect on renal function. Some foreign scholars fed the rat model of chronic renal failure with the same concentration of soybean protein and casein. The results showed that the group fed with soybean protein had a long survival time, decreased urinary protein, no protein malnutrition, slight damage to renal tissue and improved blood lipid level. Thus, the understanding of soybean protein has made new progress. Based on these new understandings, the academic circles think that it is unnecessary for CRF patients to fast legumes. Bean foods (soybean milk, tofu and its products) have high protein content, and the EAA content is higher than other plant proteins such as cereals, which is beneficial to correct the lack of EAA, and will not increase high filtration compared with animal proteins. This is not only beneficial to improving patients' nutrition, but also beneficial to improving patients' appetite, and will not adversely affect renal function. Therefore, CRF patients do not need to restrict the intake of legumes on the premise of controlling the total intake of protein and having enough EAA or α -pyruvate.