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If the applicant fails to reply to the notice of examination opinions within the time limit without justifiable reasons, his application will be regarded as withdrawn, and the Patent Office will not issue a notice before the reply period of the notice of examination opinions expires in the substantive examination procedure, so the applicant or agent must pay attention to the reply period after receiving the notice of examination opinions to ensure that the reply is submitted within the specified time limit. If you can't reply to the examination opinions for justifiable reasons, please fill in the application form for patent application abandonment.