Case. Pfizer's mRNA first appeared in the COVID-19 epidemic. Personally, I think the lack of safety research is mainly due to the lack of clinical data. However, in the face of the threat of the epidemic, it is also helpless to rush into the horse, and the whole world is similar. The actual report of adverse reactions is better than I expected, and there are no serious adverse reactions or even deaths on a large scale, so I want to disappoint some people. Speaking of this case, it is the first case officially reported, and the research level is very high, so it is suitable as a risk warning. At present, it seems to be a case, which has no clear meaning to the public. Etiology. It can only be said that it is a vaccine-related adverse reaction. Hepatitis caused by mRNA vaccine may be due to the rich content of vaccine carrier in the liver, which activates the immune cells of the liver. Since there is only 1 case, it is uncertain how much risk this highly activated T cell poses to the public.
Risk. Considering that the immune stimulation and hepatotoxicity of RNA products are the focus of product safety inspection, individuals tend to think that this case is not universal. Individuals can temporarily regard it as a specific reaction similar to allergies ... there is no way to stop it. For medical institutions, we must be prepared to deal with the risks associated with autoimmune hepatitis when using Pfizer mRNA in the future. Inactivated vaccine. At present, the incidence of general adverse reactions (such as fever) of inactivated vaccines is lower than that of mRNA, and the incidence of serious adverse reactions is even lower, which can satisfy most people's imagination of safety. However, even on Zhihu, you can see a lot of discussions about the side effects of vaccines. Although I personally don't think it can be forcibly related, there are indeed quite a few people who doubt the safety of the vaccine.
In short, the epidemic has been repeated for several years. Although everyone is very tired, for everyone's safety, we should always protect the epidemic situation so as to get rid of the virus as soon as possible.