Initially, Chen et al. showed that active agents can be used as reverse micelles or microemulsions to synthesize enamel. Recently, scientists at the University of Leeds have found a way to simulate enamel in diseased enamel, so as to regenerate enamel. They developed a patented technology to repair the regeneration of enamel. P 1 1-4 peptide monomer (curodont) can make demineralized enamel form new crystals in normal saliva. In vivo studies show that peptides can reduce demineralization and significantly increase remineralization.
So far, studies have shown that enamel-like structures can be formed by using chemical solutions or HAP films. Based on the new findings, the current research strategy holds that amelogenin is the key stage of biomineralization. Marinet proposed a method to synthesize composite amelogenin by cation selective membrane system under bionic conditions. In this method, amelogenin grows in octacalcium crystals, and slender rod-shaped crystals and crystal proteins attached to the crystals can be grown. A new electrolytic deposition technology was used to prepare bionic enamel composite coating. The electrolyte contains calcium, phosphorus ions and soluble recombinant amelogenin, and the pH value and ionic strength are physiological concentrations.