"Magic Small Molecular Active Peptides" Chapter 2 Section 3 Secretion Cycle of Active Peptides

At different ages, the secretion amount of various bioactive peptides is also very different. According to the secretion amount, a person's life can generally be divided into the following four periods:

1) The period of exuberant secretion (youth before the age of 25)

During this period, the endocrine system is full of functions, the secretion amount of various bioactive peptides is balanced, the human body has strong immune function, and the human body is generally not prone to diseases. After the age of 25, the secretion will decrease by 15% every 1 years.

2) Under-secretion period (3-5 years old, prime and middle age)

Around 3 years old, various organs and tissues of human body began to age and shrink, and their functions declined, and the secretion of various bioactive peptides was only 85% of the peak period. When people reach the age of 45, both men and women will experience a sharp decline from appearance (such as rapid skin relaxation and aging) to body physiology (hypogonadism), and the functions of human nervous system and immune system will undergo a series of changes, resulting in various related sub-health states and mild disease symptoms.

3) Secretion deficiency period (middle age and old age over 5 years old)

At the age of 6, the secretion of active peptides is only about 1/5 of the peak period, and at the age of 8, it is only less than 1/1. During this period, if there is a serious shortage and imbalance of active peptides, there may be very prominent aging symptoms or various related diseases.

4) Secretion termination period

During this period, due to the decline of cell function, organ failure and loss, active peptides are no longer secreted, which leads to the end of life. With the natural aging of the human body, the number of active peptides secreted by the human body will gradually decrease. However, the fast pace of modern life, fierce competition for survival, great emotional pressure, environmental pollution, unhealthy diet structure and other factors have caused the human body to be in a "sub-health" state, with the overload of various functional organs and the decline of physiological functions. Exogenous small molecular peptides not only have strong nutritional value, but also have the function of regulating human metabolism and physiology, which is very important for maintaining normal life activities. Therefore, it is very beneficial for any population to supplement exogenous small molecular peptides.

reference

[1] Li Yong. Peptide clinical nutrition [m]. Beijing: Peking University Medical Press, 212.

[2] Feng Xiuyan, Ji Cheng. The role of oligopeptides in nutrition in protein [J]. Acta Animal Nutrition, 21,13 (3): 8-13. Sidhu g s the active ABS option of amino-acids by the intention [j]. Physiol., 1953,121 (2): 255-263.

[4] Neway H, Smith P H . Intercellular hydrolysis of dipeptides during intestinal absorption[J].Physiol.,1996, 152: 367-38.

[5] Daniel H. molecular and integrated physio1ogy of intentional peptide transport [j]. Annual Rev. Physiol., 24, 66: 361-384.

[6] Zaloga G P. Physiology Effects of peptides based on intestinal formula [J]. Nutrition in clinical practice, 199, 5:231—237.

[7] Hara H,Funabili M,Iwata,et al . Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr.,1984, 114:1122—1129.

[8] Leonard J V,Marrs T C,Addison J M,et al. Intestinal absorption of amino acids and peptides in Hartnup disorder[J].Pediatr Res., 1976, October (4): 246-249 < P > [9] Li Guannan, Xia Xuejuan, Long Yaohang, et al. Research progress and application of antimicrobial peptides [J]. Acta Animal Nutrition, 214, 26 (1): 17-25.

[1] Wang Chunyan. 31 (13): 37-311.

[11] Li Shimin. Research progress of food-borne active peptides and blood pressure lowering [J]. Geriatric Health Care, 28,14 (2): 125-127.

[12] Dziuba J, Minkiewicz P, Nalecz D. et al. Database of biologically active peptide sequences[J].Nattrunges.,1999,43:19—195.‘

[13] Shin Z,Yu R,Park S A,et al. His-His-Leu , an angiotensin 1 converting enzyme inhibitory peptide derived from Korean soybean paste, Exerts Arlithihypertensive Activity in vivo [J]. J Agric Food Chem., 21,49 (6): 34-39.

[14] Hirasawa M, Shijubo N, Uede T, et al. Integhn expression and ability to adhere to extracellular matrix protelns and endothelial cells in human lung cancer lines[J].Br J Cancer., 1994,7(3):466—473.

[15] Florentin l,Chung V,Martinez J, et al. In vivo immuno-pharmacological properties of tuftsin(Thr-Lys-Pro-Arg)and some analogues[J].Methods Find Exp Clin Pharmacol.,1986, 8(2):73—8.

[16] Tsuchita H,Suzuki T, Kuwata T.The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats[J].Br J Nutr.,21, 85 (1): 5-1.

[17] Zhang Hao, Ren Fazheng. Research progress of natural antioxidant peptides [J]. Food Science, 28,29 (4): 443-447.

[18] Zhang Lili, Yan Qunfang, Wang Tian. Isolation and antioxidant activity of soybean bioactive peptides. Xie Bijun. Study on antioxidant effect of soybean peptide in vitro [J]. Food Science, 22,23 (11): 118-12.

[2] Cui Jian, Li Zhaolong, Hong Xiaoying Yin. Free radical biological antioxidant and diseases [J]. Journal of Tsinghua University, Natural Science Edition, 2,4 (6). Zhuo Wang. Research progress of antitumor effect of small molecular peptides [J]. Journal of Tianjin Medical University, 25,11 (3): 499-52.

[22] Chène P, Fuchs J, Bohn J, et al. A small synthetic peptide, Which contains the p53-hdm2 interaction, stimulates the p53 pathway in tumor cell lines [j]. j mol biol., 2,299 (1): 245-253.

[23] Issaeva N, Friedler A,Bozko P,et al. Rescue of mutants of the tumor supPressor p53 in cancer cells by a designed peptide[J].Proc Natl Acad Sci USA.,23, 1 (23): 1333-1337.

[24] Zhu Weiming. The role change of clinical nutrition: from nutritional support to diet therapy [J]. Parenteral and Enteral Nutrition, 29,16 (1): 1-3l. < P > [25] Pei Xinrong, Yang Fen 42 (4): 235-238. < P > [26] Liang Rui, Zhang Zhaofeng, Zhao Ming, et al. Promoting effect of marine collagen peptide on wound healing in rats undergoing cesarean section [J]. China Gong * * * Health, 21,26 (9): 1144-1145. < P > [21] 29 (2): 6-68.

[28] He Average. Research progress of anti-tumor oligopeptide drugs [J]. China Pharmaceutical Biotechnology. 29,4 (4): 288-29.

[29] Sun Lichun, COY David H. Research progress of polypeptide drugs [J]. Sheng Y,et al. The antihypertensive effect of peptides:a novel altemative to drugs? [J]. Peptides, 28,29 (6): 162-171.

[31] Nie Caihui, Xu Hanmei. Development status of polypeptide drugs [J]. Pharmaceutical Progress, 214,38 (3): 1: 6-22. < P > [