Compound glycyrrhizin injection has the best efficacy in the auxiliary treatment of acute eczema, followed by chronic eczema, slightly less efficacy in neurodermatitis, and the worst efficacy in seborrheic dermatitis; in effective cases, the effective time The average recovery time was significantly shorter than that of the control group. Among them, the efficacy on eczema is consistent with the results reported by Yu Liping and others.
The effective mechanism of Compound Glycyrrhizin Injection in the auxiliary treatment of eczema and dermatitis skin diseases may be: (1) Its main components are glycyrrhizic acid monoamine, glycine and cysteine. These three ingredients can* **Coordinated to exert anti-allergic effects; ⑵ By inhibiting the activity of phosphatase A2 (PLA2), blocking the metabolic level of arachidonic acid in the initial stage and exerting anti-inflammatory effects; ⑶ Glycyrrhizic acid monoamine and adrenocortical hormones Various metabolic enzymes, such as △5β reductase, 11β-HSD (11 steroid dehydrogenase) and 20-HSD, have strong affinity and inhibit the inactivation of steroids in the liver, thereby slowing down the metabolism of steroids and making them more effective. Enhance, thereby exerting steroid-like effects.
In summary, compound glycyrrhizin injection is safe, has anti-allergic, steroid-like effects and regulates the body’s immune function to a certain extent [3], and can be used for eczema and dermatitis. Adjuvant treatment of skin diseases.