2
Blood will continue to coagulate and re-form thrombus, which is also the main reason for the high recurrence rate of thrombolytic drugs. However, Danao can regulate blood balance, inhibit platelet aggregation and promote prostacyclin PGI with the function of dissolving platelets.
2
The formation of thrombus depends on the biochemical reaction mechanism of blood itself, which makes thrombus dissolve. It can be said that the most striking feature of Dan 'ao is that it treats both the symptoms and the root causes and is not easy to relapse. Patients with cerebral thrombosis cause local cerebral ischemia and hypoxia, which reduces the intensity of cerebral vessels. Under the action of fibrinolytic drugs such as fibrin, the incidence of bleeding complications of cerebral infarction can be increased by 9.3%~20% due to the compensatory fibrinolytic mechanism in vivo, which increases the treatment risk. However, Danao achieves the effect of thrombolysis by mediating blood balance, so Danao has a quick effect. Patients with acute severe cerebral thrombosis can take effect in 3 days, and clinical proof shows that there is no 65438. Danao is a fully chemically synthesized anti-cerebral thrombosis drug, which avoids the transient and rejection adverse reactions of other biological agents in the process of medication, does not need to do allergic experiments, and is convenient to use. To sum up, Danao is the first choice of antithrombotic drugs with definite curative effect, rapid treatment, treating both the symptoms and root causes, safe medication and convenient use, and has therapeutic and preventive effects.
Clinical observation of sodium ozagrel in the treatment of ischemic cerebral infarction
[
2006-5- 12
15:37:55
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Author:
dfhgfh
]
Keywords: sodium ozagrel
Sodium ozagrel for injection is a specific inhibitor of thromboxane synthase and a new antithrombotic drug first developed by Xiaoye Pharmaceutical Factory. In China, the drug has been successfully studied by Dandong Pharmaceutical Factory. Clinical trials have proved that the drug has a good anti-platelet aggregation effect. Clinically, it is mainly used to treat cerebral thrombosis and its accompanying dyskinesia. From August 2003 to August 2004, 50 patients were observed and treated with sodium ozagrel (trade name: Danao) in our hospital, and all of them achieved obvious results. The report is as follows.
1
Materials and methods
1. 1
general specification
All 50 patients were newly diagnosed, including 32 males and 8 females/kloc-0, with an average age of 59.4 years. All of them met the standards adopted by the second national symposium on cerebrovascular diseases, and CT plain scan was diagnosed as cerebral infarction. All patients were hemiplegic, with mild muscle strength grade ⅳ, moderate muscle strength grade ⅱ ~ ⅲ and severe muscle strength grade 0 ~ ⅰ.
1.2
therapeutic method
80mg of sodium ozagrel was added to 500ml of 5% glucose injection, and intravenous drip was given every morning and evening 1 time for 2 weeks.
2
Evaluation criteria of curative effect and treatment result
According to the scoring standard of clinical neurological deficit in stroke patients, every patient was given a detailed neurological examination before and after treatment 1 day of day 4, and the score was given. The curative effect evaluation is based on the standards formulated by the second national conference on cerebrovascular diseases. The curative effect grade is divided into: basically recovered, markedly effective, effective, unchanged, deteriorated and dead. The specific criteria are as follows: basic recovery: the degree of disability is 0, and the neurological deficit score is reduced by 9 1%~ 100%. Remarkable effect: the neurological deficit score decreased by 46%~90%. Effective: the neurological deficit score decreased 18%~45%. No change: the neurological deficit score decreased by 0~ 17%. Deterioration: The neurological deficit score increased instead of decreased. See table 1 for the results.
Among the 50 patients who completed the whole course of treatment, liver and kidney functions were normal, and 3 cases had adverse reactions, mainly manifested as nausea and skin fever. There were 1 patients with rash, and all patients could complete the course of 14 days without special treatment.
Table 1
Therapeutic effect of patients with cerebral infarction
(omitted)
three
discuss
The main component of sodium ozagrel is sodium trans -3-[4( 1H- imidazole-1- methyl) phenyl ]-2- acrylate. Clinical experiments show that cerebrolysin is the most effective antithrombotic drug for cerebral thrombosis in China at present, and the cure rate and effective rate are 94%. Most fibrinolytic antithrombotic drugs only act on formed thrombus and do not affect TXA which can aggregate platelets.
2
Blood will continue to coagulate and re-form thrombus, which is also the main reason for the high recurrence rate of thrombolytic drugs. However, Danao can regulate blood balance, inhibit platelet aggregation and promote prostacyclin PGI with the function of dissolving platelets.
2
The formation of thrombus depends on the biochemical reaction mechanism of blood itself, which makes thrombus dissolve. It can be said that the most striking feature of Dan 'ao is that it treats both the symptoms and the root causes and is not easy to relapse. Patients with cerebral thrombosis cause local cerebral ischemia and hypoxia, which reduces the intensity of cerebral vessels. Under the action of fibrinolytic drugs such as fibrin, the incidence of bleeding complications of cerebral infarction can be increased by 9.3%~20% due to the compensatory fibrinolytic mechanism in vivo, which increases the treatment risk. However, Danao achieves the effect of thrombolysis by mediating blood balance, so Danao has a quick effect. Patients with acute severe cerebral thrombosis can take effect in 3 days, and clinical proof shows that there is no 65438. Danao is a fully chemically synthesized anti-cerebral thrombosis drug, which avoids the transient and rejection adverse reactions of other biological agents in the process of medication, does not need to do allergic experiments, and is convenient to use. To sum up, Danao is the first choice of antithrombotic drugs with definite curative effect, rapid treatment, treating both the symptoms and root causes, safe medication and convenient use, and has therapeutic and preventive effects.