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Since ancient times, ginseng has been used as a noble medicinal material to nourish and strengthen the body, and is regarded as the king of medicines in the field of traditional Chinese medicine. Considered a panacea for all symptoms. In recent years, there has been a new term that can more appropriately describe the preciousness of ginseng: adaptogen. The name adaptogen is not an ancient medical term, but was developed in recent years by Soviet scientists Brickman and Radhelev. Based on the properties of ginseng, they call drugs that can enhance the body's existing resistance and strengthen the body's functions "adaptogens." What are ginsenosides?
Ginsenoside (Ginseng Saponin) is the general name for saponins isolated from ginseng and plants of the same genus (such as Panax notoginseng, American ginseng, etc.). It belongs to the triterpenoid saponins and is the main active ingredient of ginseng. . At present, more than 60 saponins have been isolated, some of which have been proven to have a wide range of physiological functions and medicinal value. Ginsenosides mainly exist in the phloem part of ginseng, 3.5~5.5% in the ginseng body, 4.0~6.0% in the branch roots, 7.6~9.6% in the reed heads, and 8.0~8.8% in the fibrous roots.
From a structural point of view, ginsenosides are bioactive small molecule compounds formed after glycosylation of sapogenins. The so-called saponins (Glucosides, Saponines) refer to natural compounds composed of sugar bodies (one or more) and aglycones (triterpenes or steroids). They are glycoside-type natural compounds. Since these compounds are easily dissolved in water, It is also called saponin because of its foaming properties. Microbial fermentation functional fungal biotechnological transformation method
Each saponin has its own unique function. The content in natural ginseng is very small, it is difficult to obtain, and the cost of purification and transformation is high and the price is high. Among them, ginsenosides Rh2, Rh3 and rare saponins are precious and high-priced saponins, and their content in red ginseng is only 0.001% and 0.03%. Rare saponins are metabolites of human intestinal bacteria and do not exist in any ginseng, so their value is particularly precious.
Huide Biotechnology Co., Ltd. uses appropriate microbial strains to perform a fermentation process to change the functional group structure of the raw material compounds, which is referred to as the "functional group fungal biotechnology transformation method" (Functional Group Fungus Bioconversion Method)", which can use alternative raw materials for effective extraction, then use fungi with special selectivity to change the structure of the functional groups, and finally use purification technologies such as chromatography and supercritical extraction to extract High-purity specific ginsenosides, such as ginsenosides Rh2, Rg3 and rare saponins; the manufacturing method developed by this R&D team not only reduces production and raw material costs, but also improves the purity of the product and also develops new compounds for Extract raw materials with high difficulty or high purity requirements, conduct biological activity research and apply for patents.
The anti-cancer principle of ginsenosides Rh2, Rh3 and rare saponins
Ginsenoside Rh2 has an inhibitory effect on the enzymes in the preparation phase of cancer cell replication and can block the progression of G1→S phase. . It can inhibit the production of P-glycoprotein by cancer cells and increase the sensitivity of cancer cells to chemotherapy drugs. It can accelerate the recovery of white blood cells after chemotherapy and radiotherapy and quickly improve immunity.
Ginseng saponin Rh3 inhibits the synthesis of proteins and ATP in the early stages of mitosis of cancer cells in the G2→M phase of the cell proliferation cycle, and slows down the proliferation and growth rate of cancer cells. Induces tumor cell apoptosis, inhibits cancer cell neovascularization and avoids tumor invasion and metastasis. Increase the activity of NK immune cells and improve human immunity.
Rare saponins can activate the activity of Caspase-3 enzyme and induce apoptosis of cancer cells. Regulates apoptosis-related proteins, leading to cancer cell apoptosis. Inhibits HSE cells from forming blood vessels and blocks the nutrient source of cancer cells. Topics: Nangang Exhibition Hall, Biotechnology Exhibition