[Invention Patent] [Invention Authorized Patent] Melatonin Double-layer Controlled Release Tablets and Preparation Process - CN02133887.6 Valid Patent
Applicant: Chongqing Taiji Medical Research Institute
p>Application date: 2002-10-09 - Main classification number: A61K31/4045
Abstract: Melatonin double-layer controlled-release tablets and their preparation process, which use melatonin as the main raw material , a double-layer tablet composed of an immediate release layer and a sustained release layer. The immediate release layer is composed of: melatonin 1-5, vitamin B6 3-15, lactose 10-70, pregelatinized starch 10-70, hydroxyl Propylmethylcellulose 0.03-0.3, magnesium stearate 0.3-2, silicon dioxide 1.0-3.0; the composition of the sustained-release layer is: melatonin 2-6, hypromellose 15-60, stearic acid 15 -65, polyethylene glycol 10000 10-30, magnesium stearate 1.0-5.0. This product uses quick-release and sustained-release double-layer tablets for the first time, which enables the product to have a rapid hypnotic effect and extend the effective sleep time, which can make up for the shortcomings of short hypnotic time or slow onset of effect of existing melatonin products on the market. .