He has been engaged in the basic research on the mechanism of oomycete disease and the application of plant disease control for a long time, and systematically studied the rapid detection and disease diagnosis technology of quarantine pathogens, the molecular regulation mechanism of Phytophthora development process and the molecular mechanism of interaction between Phytophthora and plants. He presided over more than 30 national public welfare industry scientific research projects, national 863 plan projects, national natural science foundation, national 973 plan sub-projects and 948 projects. Main academic contributions: (1) explained the virulence variation mechanism of Phytophthora sojae, and cloned two new avirulent genes Avr 1d and Avr3b；; It was explained that the main avirulent genes in Phytophthora sojae population in China had complex toxicity variation through point mutation, transposon insertion and differential transcription. It is proved that the toxic proteins of Phytophthora can interfere with the innate immunity of plants to pathogens. It is found that Avr3b, the effector molecule of Phytophthora infestans, can simulate the action of plant defense response inhibitors and interfere with plant disease resistance. The above research results have important theoretical and practical value for improving plant disease resistance. (2) The molecular mechanism of Phytophthora sojae's host recognition was clarified, and it was found that Phytophthora sojae recognized isoflavones secreted by soybean roots through G protein-coupled receptors and G protein signaling system regulation, so as to find host plants; G-protein-coupled receptors are involved in regulating the reception of mating sex hormones by Phytophthora, thus controlling the sexual reproduction process of Phytophthora. This study provides an important theoretical basis for screening new drugs to control epidemics. (3) The molecular mechanism of plant non-host resistance to Phytophthora was explained, many new toxic proteins secreted by Phytophthora were identified, and the role of cell signaling systems such as MPAK in plant non-host resistance to Phytophthora was clarified. (4) A number of molecular targets that can be used for molecular monitoring of pathogenic bacteria in quarantine harmful plants have been found, and on this basis, more than ten kinds of rapid detection technologies for pathogenic bacteria have been developed, forming a number of national and industrial standards, which have been widely promoted and applied.
He has successively won three natural science awards and scientific and technological progress awards from the Ministry of Education, and published more than 20 research papers/kloc-0 in domestic and foreign journals. Among them, more than 70 papers have been published in SCI journals such as Science, Nature genetics, Plant Cell (cover article), PLoS Pathogens, New Physiology, Molecular Microbiology and MPMI. Among them, 36 articles are first authors or associated authors, and the total impact factor exceeds 120. Four papers were selected as highly cited papers by ESI, and were cited by SCI publications for nearly 700 times. He made invited reports at important international academic conferences 10 and participated in organizing international academic seminars for 6 times.
He has obtained 6 national invention patents and published 3 textbooks or works. He has been selected as the outstanding talents of the Ministry of Education in the new century, the academic leader of Nanjing Agricultural University's "133 Talent Project", the outstanding postgraduate tutor and excellent teacher of Nanjing Agricultural University, the academic backbone of "Blue Project" in Jiangsu Province, the outstanding scientific and technological workers in Jiangsu Province, and the leader of the outstanding scientific and technological innovation team in Jiangsu universities.