1: Use phenylacetonitrile to brominate with bromine to generate α-bromophenylacetonitrile, and then condense it with benzene in the presence of anhydrous aluminum trichloride to obtain diphenylacetonitrile, and combine the latter with dimethyl This product is prepared by the condensation of isopropylamine with the participation of -.
2: Methadone Hydrochloride
The preparation of Methadone starts with propylene oxide, amination with dimethylamine, and oxidation and condensation to obtain 4-dimethylamino- 2,2-diphenylvaleronitrile (an isomer insoluble in n-hexane) reacts with ethylmagnesium bromide, hydrolyzes to obtain methadone, and finally forms a salt with hydrochloric acid.