1983 studied in Medical College of Henan University. 1988 was admitted to the postgraduate of pathophysiology (mainly immunopathology) in Suzhou Medical College. 199 1 After obtaining a master's degree in medicine, he was assigned to Kailuan Hospital affiliated to North China Coal Medical College to engage in clinical work such as respiratory medicine, digestive medicine, emergency department and ICU.
Chinese name: Xiao Su.
Nationality: People's Republic of China (PRC).
Ethnic group: Han nationality
Place of birth: Henan
Occupation: doctor
Graduate school: Medical College of Henan University
Masterpiece: Diagnosis and treatment of acute renal failure.
Biographical notes
1983 studied in Medical College of Henan University. 1988 was admitted to the postgraduate of pathophysiology (mainly immunopathology) in Suzhou Medical College. 199 1 After obtaining a master's degree in medicine, he was assigned to Kailuan Hospital affiliated to North China Coal Medical College to engage in clinical work such as respiratory medicine, digestive medicine, emergency department and ICU. Engaged in scientific research in Tangshan Gallstone Research Center. Served as the internal medicine course of North China Coal Medical College. From 65438 to 0997, he was promoted to deputy chief physician, and served as director of ICU, director of internal medicine teaching and research section, invited editor of China Coal Industry Medicine magazine, and member of Chinese Medical Association of Kailuan Hospital affiliated to North China Coal Medical College. Published more than 20 national papers. He has undertaken three provincial and ministerial scientific research projects, namely, study on the influencing factors of chemiluminescence of human peripheral blood lymphocytes, study on the internal environment of human biliary tract and the factors of stone formation, and study on the prognosis of post-traumatic multiple organ dysfunction syndrome. Won the Hebei Provincial Science and Technology Progress Award 1 item, and the Tangshan Science and Technology Progress Award won 2 first prizes.
In 2000, he was admitted to Shanghai Medical College of Fudan University. He studied under Professor He Lixian, a famous infection expert, and Professor Bai, an expert in respiratory medicine, and engaged in the study of acute lung injury. In 2002, he went to America. In 2004, he completed his doctoral thesis "Effect of activation of protease-activated receptor 2 on respiratory and circulatory functions" at the University of California, San Francisco, USA, and obtained a doctorate from Fudan University. From 2004 to 2007, he worked as a postdoctoral fellow at the Cardiovascular Institute of the University of California, San Francisco, and studied under Professor MichaelA. Matthay, a world-renowned expert on acute lung injury and editor-in-chief of AJP: Lung, said. From 2007 to 2009, he worked as a research assistant professor in the Department of Pharmacy, University of Illinois at Chicago, USA, and won the Parkerbrancislung Biomedical Award. 2009-20 1 1, Assistant Research Fellow, Cardiovascular Institute, University of California, San Francisco. 20 1 1-20 12 Associate Research Fellow, Department of Anesthesiology, University of California, San Francisco. On March 20/0/2, Kloc joined Shanghai Pasteur Institute of China Academy of Sciences as a researcher and doctoral supervisor, and was selected into the Hundred Talents Program of China Academy of Sciences.
research direction
(1) Molecular mechanism and treatment measures of lung infection, inflammation and tissue injury (acute lung injury, acute respiratory distress syndrome, sepsis); (2) Controlling the occurrence and development of acute inflammation and injury by regulating the migration of neutrophils; (3) Repair mechanism of bone marrow stem cells on lung infection, inflammation and tissue injury; (4) The mechanism of cholinergic anti-inflammatory pathway on bone marrow migration of bone marrow stem cells and directional chemotaxis of injured tissues. During his stay in the United States (20-2012, 2002), he published more than 20 SCI papers in famous magazines such as Journalofimmunology, Journaloficlinicalinvestment and Natural Medicine, with the first author 14 and nine corresponding authors. The total impact factor (IF) is 150. The article cited 1200 times. Published abstracts of nearly 20 international papers. Deputy editor-in-chief of Medical Quarterly (IF 2.325); Editors of PLoS ONE (IF 4.092), WorldJournalifimmunology, WorldJournalofSpirology, WorldJournalofPortology, etc. He has served as a reviewer and reviewer of more than 20 SCI magazines, such as Journalofimmunology (IF 5.788), American JournalofSpiritoryand and Documentary Medicine (IF11.08). He has been invited to speak at international conferences many times. Received three grants, including NIH Fund and ParkerB. Francis prize. An American patent. He is currently a member of the American College of Chest Physicians, the American Physiological Society and the New York Academy of Sciences. During my work in China (199 1-2002), I published more than 20 medical papers (including respiratory and critical diseases and traumatic critical diseases) (mostly the first author and correspondent). Won 4 provincial and municipal scientific research awards. Participated in writing two academic works on respiratory system and critical diseases.
Summary of scientific research work
1. Molecular mechanism of lung infection, inflammation and immunity. It is found that vagus nerve -α7 nicotinic acetylcholine receptor participates in lung inflammatory injury caused by respiratory tract infection by regulating macrophages and neutrophils (Sux et al., Journal of Immunology, 20 10). It was found that the interaction between neutrophils and platelets participated in the occurrence and development of pulmonary cystic fibrosis inflammation (Sux, et al. Infection Research, 20 1 1). Discover the molecular mechanism of integrin-related protein (CD47) regulating neutrophil migration to mediate endotoxin and Escherichia coli-induced acute lung injury (Sux et al., Journalofimmunology, 2007); Discover the molecular mechanism of neurogenic lung inflammation and edema caused by the activation of protease-activated receptor 2(PAR2) (Sux et al., Journalofimmunology, 2005); Participate in discovering the role of protease-activated receptor 1(PAR 1) in lung inflammatory injury caused by mechanical ventilation (the second author. Journal of Clinical Inflammation, 2006); It was found that aquaporin 1 played a role in endotoxin-induced acute lung injury (Su et al., Respiratory Europe Biology, 2004). This paper mainly studies how vagus nerve -α7 nicotinic acetylcholine receptor pathway regulates the escape and recruitment of bone marrow neutrophils under infection and inflammation.
2. Treatment of lung infection and inflammatory injury (bone marrow mesenchymal stem cells). It was found that activating α7 nicotinic acetylcholine receptor mobilized bone marrow stem cells to repair acute lung injury induced by Escherichia coli. Participated in the discovery that the application of mesenchymal stem cells in lung to treat endotoxin-induced acute lung injury (the second author, JournalofImmunology, 2007) reduced the mortality rate of acute lung injury; α7 nicotinic acetylcholine receptor agonist was used for the first time to treat acute lung injury induced by acid inhalation, endotoxin and Escherichia coli (Sux, et al. Amjrespiricellmolbiol, 2007; SuX and so on. JournalofImmunology，20 10)； The protective effect of ambroxol on endotoxin-induced acute lung injury was first discovered (Sux et al., intensive care, 2004). Firstly, the therapeutic effect of hemofiltration on improving hemodynamics was verified in the dog model of oleic acid-induced acute lung injury (Sux et al., Intensive Care, 2003). This paper focuses on how vagus nerve -α7 nicotinic acetylcholine receptor pathway regulates the escape of bone marrow stem cells and participates in the repair of injury under infection and inflammation.
3. Develop the research methods of lung inflammation injury immunity. Firstly, the method of intratracheal instillation (DVI) under direct vision was discovered and applied to the replication of acute lung injury model in mice (Sux, et al. Explungres, 2004). Participated in replicating the mouse model of transfusion-related lung injury (TRALI) (second author, JournalOfClinicalInjury, 2006); A method for determining central venous pressure (CVP) in mice was developed for the first time (SUX et al., Amjphysiollungcellmol Physiol, 2006). The receptor for advanced glycation end products (RAGE) was first used as a marker of lung epithelial type I cell injury to distinguish between direct and indirect acute lung injury (Sux, et al. Amjphysiollungcellmol, 2009).
Recent funding
Knowledge Innovation Project of China Academy of Sciences; China Academy of Sciences Hundred Talents Program; General Project of National Natural Science Foundation of China; Shanghai key basic research project; ParkerB, USA Francis prize.
Editorial Committee reviewer
Deputy editor-in-chief of Medical Quarterly (IF 2.325); PLOSONE(IF4.092) Editorial Board, WorldJournalofImmunology, WorldJournalofRespirology and WorldJournalofepatography Editorial Board. He has served as journal of immunology, Journal of Lymphocyte Biology, Journal of Natural Medicine, Journal of Cell Research, Journal of Molecular Biology, American Journal of Physiology-Journal of Molecular Physics of Lung Cells, American Journal of Respiratory and Molecular Biology, American Journal of Respiratory and Critical Medicine, Journal of Critical Medicine, Journal of Applied Physiology, Biomedical Genomics, etc.
Compile academic works
Xiao Su. Diagnosis and treatment of acute renal failure. Practical critical care medicine, edited by Cui. Tianjin Science and Technology Press, 2000.
Xiao Su. Experimental methods of acute lung injury. White editor of acute respiratory distress syndrome. Shanghai Science and Technology Press, 2005.
clinical experience
He used to be the director of intensive care unit of Kailuan Hospital affiliated to North China Coal Medical College (1997-2000). Good at monitoring (hemodynamics, respiratory physiology, etc.) and other ICU rescue and treatment technologies. ), mechanical ventilation, nutritional support (enteral and deep venous nutrition), venous catheterization (Swan-Ganz catheter, central vein, etc. ), hemofiltration, etc. Lead the intensive care unit to undertake the rescue of critically ill patients in hospital, out of hospital and in gynecology and pediatrics. Responsible for the monitoring and treatment of patients after major surgical operations, especially in departments such as heart surgery, brain surgery and abdominal surgery. Responsible for the first aid, consultation and treatment of trauma in the Kailuan Sub-center of Mine Medical Rescue of the State Administration of Work Safety, which contributed to the success rate of 1.000% in rescuing critically ill patients. Established medical cooperation relationship with Department of Critical Care Medicine of Peking Union Medical College Hospital (Professor Liu Dawei) and Emergency Center of Tianjin Medical University General Hospital (Professor Cui). As a specialist, he is good at the diagnosis and treatment of common diseases in respiratory medicine, especially at the rescue of critical patients such as acute attack of COPD, acute respiratory failure, acute respiratory distress syndrome, acute heart failure and multiple organ failure.
Teaching experience
As an assistant professor, he taught pathology, pathophysiology and immunology for two years (1986- 1988). 1997-2000: Adjunct associate professor of internal medicine of North China Coal Medical College, director of internal medicine teaching and research section of Kailuan Hospital affiliated to North China Coal Medical College, teaching undergraduate chapters on respiratory failure, heart failure, mechanical ventilation, medical diagnosis and treatment of critical illness, etc. During my work in the Institute of Respiratory Diseases of Fudan University and the Department of Respiratory Medicine of Zhongshan Hospital affiliated to Fudan University, I assisted in guiding doctoral students' scientific research. He has assisted and guided the research work of graduate students and college students at the University of California at San Francisco. 20 12 set up a pathological group of respiratory tract infection to guide doctoral and postdoctoral students.
Representative papers
1.SuX*、FengX、TerrandoN、YanY、ChawlaA、KochLG、BrittonSL、MatthayMA、Mazem。 The dysfunction of inflammatory decomposition pathway is related to the decollement model of cognitive metabolic syndrome after Dwight Xaggerated. Molmed.20 12， 18: 148 1- 1490。 * communication.
2.SuX*。 Guiding neutrophils into alveoli: Who is the decision maker? amjrespircritcaremed . 20 12； 186:472-3.* Correspondence author.
3.SuX*、MatthayMA、MalikAB。 Inhibition of acute inflammatory injury induced by gram-negative bacteria vision. jimmunol . 20 10； 184: 401-410. * Correspondent.
4.SuX*、LeeJW、MatthayZA、MednickG、UchidaT、FangX、GuptaN、MatthayMA。 Activation of α7 nicotinic acetylcholine receptor reduces uric acid-induced acute lymphoblastic leukemia. Amjrespiricellmolbiol.200737:186-192. * Correspondent.
5.SuX*, Johansson, Runimur, Browney, Matayima. Cd47-deficient protective pneumonia: acute lung injury induced by lipopolysaccharide and Escherichia coli pneumonia. Jimmunol.2008180: 6947-53. * Correspondent.
6.SuX*，RobriquetL，FolkessonHG，MatthayMA。 Protective effect on endogenous β -adrenergic cells. 290:L769-776。 * Correspondence author.
7.SuX，CamererE，HamiltonJR，CoughlinSR，MatthayMA。 Neuropeptide-dependent mechanism of acute inflammation induced by par 2 activation. JImmunol.2005 175:2598-2605.
8.SuX*，LooneyMR，NaveenG，MatthayMA。 Receptorforadvancedglycation end-products (rage) is a direct index of experimental lung injury. amjphysiolungcellmolphysiol . 2009； 297:L 1-5。 * Correspondence author.
9.SuX*，LooneyMR，SuH，LeeJW，SongY，MatthayMA。 roleofctrexpressed byneutrophilsinmodulatingacutelunginflaminationandjurinmices . inflamres . 20 1 1； 60:6 19-32.* correspondent
10.JenkinsRG，SuX，SuG，ScottonCJ，CamererE，LaurentGJ，DavisGE，ChambersRC，MatthayMA，SheppardD。 Linking protease-activated receptor 1 enhances α(v)β(6) integrin-dependent TGF-β activation and promotes acute injury. JClinInvest.2006 1 16: 1606- 16 14.
1 1.LooneyMR，SuX，VanZiffleJA，LowellCA，MatthayMA。 Neutrophils and their fcγ receptors are very important in the model of acute lung injury associated with blood transfusion in mice. JClinInvest.2006 1 16: 16 15-23.
12. Guptan, Sussex, popov, Li You, Serikov, Matayima. Survival rate and mortality of mice transplanted with bone marrow mesenchymal stem cells by intrapulmonary administration. JImmunol.2007 179: 1855- 1863.
13. Matheima, Sussex. Natural Medicine, 2007; 13:780-78 1.
14.SuX*，MatthayMA。 Roleofproteas activated receptor 2 experimental lung injury and pulmonary fibrosis. AnatRec(Hoboken). 2009； 292:580-586.* Correspondent.