The success of Academia Sinica in "opening the door" to the blood-brain barrier and allowing drugs to enter will enhance the therapeutic effect of brain cancer.

If this gene is removed, how can you eat it without getting fat? ! Whether the placenta is healthy or not will affect the risk of schizophrenia. Old bacteria from Irish soil can prevent the new discovery of cancer immunotherapy! The reprogramming of skin cells into dendritic cells is the key to brain tumors, which refers to the abnormal proliferation of local brain, and then forms a huge tumor block, which may invade surrounding or distant cells and lead to brain cancer. Compared with other cancers, the incidence of brain cancer is relatively low, but the mortality is high. In addition to the rapid growth of cancer cells, another factor is that drugs are difficult to penetrate the blood-brain barrier. However, the good news is that Xie Qinghe's research team at the Institute of Biomedical Sciences of China Academy of Sciences found that intravenous injection of extremely low-dose vascular growth factor (VEGF) can open the blood-brain barrier, effectively deliver nano-chemotherapy drug LipoDox to the brain tumor site, and double the survival time.

Hypoxemia will block drugs during the survival period of brain cancer.

Blood-brain barrier (BBB) refers to a "barrier" between blood vessels and the brain, which selectively prevents certain substances from entering the brain from the blood. Xie Qinghe said that the blood-brain barrier will block most drugs. The most common malignant tumor in the brain is glioblastoma multiforme. After diagnosis, patients usually only have a life span of about 12~ 15 months. Because of the rapid spread, even surgery can not completely remove all tumors. Even with chemotherapy or electrotherapy, less than 5% patients can live for five years.

At present, temozolomide, a chemotherapy drug with good blood-brain barrier permeability, will make nearly 70% patients with brain cancer resistant. Therefore, the goal of this experiment is to find out that good drugs can successfully penetrate the blood-brain barrier without serious drug resistance.

Vascular growth factor can increase the particle permeability of blood-brain barrier.

In a study published in the journal of Scientific Translational Medicine on October 20th, 1999, Xie Qinghe's team unexpectedly found that injecting "vascular growth factor" into the heart can temporarily but obviously increase the degree of nanoparticles passing through the blood-brain barrier. This is because vascular growth factor (VEGF) will increase the permeability of blood vessels, and then let water and other substances in blood vessels be discharged. Therefore, it suddenly occurred to me that perhaps this discovery can be applied to promote brain magnetic resonance imaging and the delivery of chemotherapy drugs.

Xie Qinghe said that vascular growth factor (VEGF), just like the secret words of "open sesame" and "sesame closes the door", can break through the protective cover of blood-brain swelling and send drugs to treat brain cancer or other brain diseases into the brain. But remember, after opening the door, remember to close the door behind you. Because the blood-brain barrier is responsible for maintaining the physiological balance of the brain and protecting the nervous system, if the protective cover is opened for too long, dangerous substances may enter the brain and cause brain damage.

Experiments in mice prove that VEGF can help chemotherapy drugs enter the brain.

Through experiments on mice, the research team confirmed that intravenous injection of very low dose of vascular growth factor (1.5 ng/g body weight) can temporarily open the blood-brain barrier after 45 minutes, increasing the amount of substances such as nanoparticles, contrast agents, antibodies and micro-lipid chemotherapy drugs entering the brain in the blood circulation, which is about 3.5 times that of the past, and the blood-brain barrier will automatically close within about 2 hours to prevent dangerous substances from entering the brain.

In order to further understand whether drugs can effectively treat brain cancer, the research team implanted human glioblastoma into the brains of mice with gene transfer immunodeficiency, and found that this behavior would lead to the rapid death of mice, with an average life span of less than 40 days.

The treatment of tumor mice with vascular growth factor combined with chemotherapy drug micro-fat cranberry showed that the dosage of drugs entering the tumor increased by 13.6 times, and the tumor shrank without obvious side effects. Best of all, the life span of cancer mice can be extended by an average of 65 days.

The research of Academia Sinica has been patented in Taiwan Province, and will soon enter the stage of human experiment.

Xie Qinghe said that the above research results have been patented in Taiwan Province Province, and applications are being made for human clinical trials in Taiwan Province Province and the United States at the same time, hoping that the experiments can be successful and enter the stage of drug research and development, so as to benefit more patients with brain tumors and improve the cure rate of more brain diseases.

This study was published in ACS Nano on June 65438+February last year 1 1.